Analgesic Effects of Midazolam in Human Volunteers

Phase 4 Completed 24 enrolled Wilhelminenspital Vienna Akron Molecules AG · collab

RandomizedCrossoverDouble-blindBasic science

Summary

This study evaluates analgesic properties of midazolam compared to placebo and fentanyl. Each participant will receive all three drugs (midazolam, fentanyl, placebo) on three different occasions (study visits) and the effect on different pain stimuli will be tested.

Timeline

Start: 2015-12
Primary completion: 2016-03
Completion: 2016-03

Publications

Laursen DR, Nejstgaard CH, Bjorkedal E, Frost AD, Hansen MR, Paludan-Muller AS, Prosenz J, Werner CP, Hrobjartsson A. Impact of active placebo controls on estimated drug effects in randomised trials: a systematic review of trials with both active placebo and standard placebo. Cochrane Database Syst Rev. 2023 Mar 6;3(3):MR000055. doi: 10.1002/14651858.MR000055.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Fentanyl	Other / unclassified	—	—
Subject	Midazolam	Small molecule	—	—

Indications

No indication recorded.