Human Umbilical Cord-derived Mesenchymal Stem Cells With Injectable Collagen Scaffold Transplantation for Chronic Ischemic Cardiomyopathy

Phase 1/2 Completed 50 enrolled Chinese Academy of Sciences The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The study is designed to assess the safety and efficacy of allogeneic human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) with injectable collagen scaffold transplanted into patients with chronic ischemic cardiomyopathy.

Timeline

Start: 2015-10
Primary completion: 2019-08
Completion: 2019-08

Publications

He X, Wang Q, Zhao Y, Zhang H, Wang B, Pan J, Li J, Yu H, Wang L, Dai J, Wang D. Effect of Intramyocardial Grafting Collagen Scaffold With Mesenchymal Stromal Cells in Patients With Chronic Ischemic Heart Disease: A Randomized Clinical Trial. JAMA Netw Open. 2020 Sep 1;3(9):e2016236. doi: 10.1001/jamanetworkopen.2020.16236.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	human umbilical cord mesenchymal stem cells	Cell therapy	1e+08 cells	Other

Human Umbilical Cord-derived Mesenchymal Stem Cells With Injectable Collagen Scaffold Transplantation for Chronic Ischemic Cardiomyopathy

Summary

Timeline

Publications

Drugs

Indications