Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery

Summary

The investigators will conduct a prospective, randomized trial to assess the impact of neuromuscular blockade on early (\<72 hours post-ICU admission) postoperative respiratory complications in cardiac surgical patients. The study will compare continual neuromuscular blockade with cisatracurium to a single dose of succinylcholine during general anesthesia for cardiac surgery.

Timeline

Start

2016-03

Primary completion

2017-09-15

Completion

2017-09-15

Outcome

Missed primary endpoint

registry analysis (superiority test); Group CIS vs Group SUX; p = 1.00; Chi-squared NCT02635542 ↗

registry COUNT_OF_PARTICIPANTS Group CIS: 8 Participants COUNT_OF_PARTICIPANTS Group SUX: 8 Participants NCT02635542 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Cisatracurium	Small molecule	0.2 mg/kg	Intravenous
Subject	Suxamethonium	Other / unclassified	1 mg/kg	Intravenous

Indications

No indication recorded.