drugset / Trial / NCT02645734

The Effect of Bevacizumab and Ziv-aflibercept in Diabetic Macular Edema

NCT02645734

Phase 2/3 Unknown 133 enrolled Shahid Beheshti University of Medical Sciences
RandomizedParallel-groupDouble-blindTreatment

Summary

In this double clinical trial 132 patient with the history of DME (Diabetic Macular Edema) to receive intravitreous bevacizumab at a dose of 1.25mg (44 patient) , ziv-aflibercept at dose of 1.25 mg (44 patient) , ziv-aflibercept at dose of 2.5 mg (44 patient) . The study drugs were administered as often as every 4 weeks for 3 months.monitoring of best-corrected visual acuity, CST ( Central Subfield Thickness) by OCT (Optical coherence tomography) was done from base line ,4 weeks, 8weeks after injection.

Timeline

Start
Primary completion
2016-02
Completion

Drugs

EvaluationDrugModalityDoseRoute
Comparator Aflibercept Protein / enzyme biologic 1.25 mg Intravitreal
Comparator Aflibercept Protein / enzyme biologic 2.5 mg Intravitreal
Comparator Bevacizumab Monoclonal antibody 1.25 mg Intravitreal