Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Summary

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

Timeline

Start

2016-01

Primary completion

2017-07-31

Completion

2017-07-31

Drugs

Indications