drugset / Trial / NCT02651428
Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection
Phase 3
Completed
806 enrolled
CorMedix
Davita Clinical Research · collabFrenova Renal Research · collabJMI Laboratories · collabPPD Development, LP · collabSpectra Clinical Research · collab
RandomizedParallel-groupTriple-blindPrevention
Summary
The purpose of this study is determine safety and effectiveness of Neutrolin, a catheter lock solution, for prevention of central venous catheter associated bloodstream infection in hemodialysis patients.
Timeline
- Start
- 2015-12
- Primary completion
- 2018-10
- Completion
- 2018-10
Publications
- Agarwal AK, Crandon J, Hurlburt E, Michaud M, Pfaffle A, Roy-Chaudhury P, Medina C, Conway PT, Hickey EV 3rd. A plain language summary of the LOCK IT-100 study of taurolidine/heparin catheter lock solution and catheter-related bloodstream infection in hemodialysis. Future Microbiol. 2025 Sep;20(13):855-872. doi: 10.1080/17460913.2025.2547498. Epub 2025 Sep 2.
- Agarwal AK, Roy-Chaudhury P, Mounts P, Hurlburt E, Pfaffle A, Poggio EC. Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis: A Randomized, Double-Blind, Active-Control, Phase 3 Study. Clin J Am Soc Nephrol. 2023 Nov 1;18(11):1446-1455. doi: 10.2215/CJN.0000000000000278. Epub 2023 Sep 6.