Influence of Xenon Anaesthesia on Transpulmonary Pressure and Tidal Volume Distribution

Phase 4 Completed 20 enrolled Heinrich-Heine University, Duesseldorf

Non-randomizedParallel-groupOpen-labelOther

Summary

The influence of xenon anaesthesia on transpulmonary pressure and tidal volume distribution will be investigated in a prospective cohort study in 10 patients of normal weight and 10 obese patients undergoing routine xenon-based, general anaesthesia for surgery.

Timeline

Start: 2016-02
Primary completion: 2016-03
Completion: 2016-03

Outcome

Missed primary endpoint

paper without affecting Ptp [1.5 (4) vs 2.0 (4) cm H2O, P=0.15]. PMID 29793604 ↗

Publications

Background Frerichs I, Dargaville PA, van Genderingen H, Morel DR, Rimensberger PC. Lung volume recruitment after surfactant administration modifies spatial distribution of ventilation. Am J Respir Crit Care Med. 2006 Oct 1;174(7):772-9. doi: 10.1164/rccm.200512-1942OC. Epub 2006 Jul 13.
Background Zhao Z, Moller K, Steinmann D, Frerichs I, Guttmann J. Evaluation of an electrical impedance tomography-based Global Inhomogeneity Index for pulmonary ventilation distribution. Intensive Care Med. 2009 Nov;35(11):1900-6. doi: 10.1007/s00134-009-1589-y. Epub 2009 Aug 4.
Schaefer MS, Treschan TA, Gauch J, Neukirchen M, Kienbaum P. Influence of xenon on pulmonary mechanics and lung aeration in patients with healthy lungs. Br J Anaesth. 2018 Jun;120(6):1394-1400. doi: 10.1016/j.bja.2018.02.064. Epub 2018 Apr 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Xenon	Other / unclassified	—	—

Indications

No indication recorded.