Glyceryl Trinitrate Versus Lidocaine Cream for IUD Insertion

Phase 4 Completed 150 enrolled Assiut University

RandomizedParallel-groupTriple-blindTreatment

Summary

The intrauterine device (IUD) is a long-acting, highly effective, reversible contraceptive method that may be underutilized due to fear of pain during insertion. Although providers frequently prescribe non-steroidal anti-inflammatory drugs (NSAIDs) for IUD insertion, there is no evidence for any pain reduction. Women can experience high levels of pain when the IUD is placed inside the uterus, and fear of this pain could be a reason that women decide not to use this method.

Timeline

Start: 2016-10
Primary completion: 2017-05
Completion: 2017-06

Publications

Abbas AM, Ragab E, Abd Ellah NH, Sabra A, Ali SS, Mohamed A, Yosef AH. Effect of topical glyceryl trinitrate cream on pain perception during intrauterine device insertion in multiparous women: A randomized double-blinded placebo-controlled study. J Gynecol Obstet Hum Reprod. 2019 Nov;48(9):715-718. doi: 10.1016/j.jogoh.2019.03.007. Epub 2019 Mar 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	1 ml	Topical
Subject	Nitroglycerin	Unknown	1 ml	Topical

Indications

No indication recorded.