drugset / Trial / NCT02726711

Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic

NCT02726711

Phase 1 Active not recruiting 2 enrolled Vanderbilt University
RandomizedCrossoverSingle-blindBasic science

Summary

The purpose of this study is to learn more about the regulation of the veins of the abdomen by the autonomic (involuntary) nervous system, and how this may affect high blood pressure. Normally, the autonomic nervous system controls how much blood flows in the veins. In people with high blood pressure, however, the autonomic nervous system is changed. This change may affect the way blood flows in the veins of the abdomen which may play a role in their high blood pressure. About 32 participants will be screened for the study. The investigators estimate 16 will be eligible to participate in all of the study days.

Timeline

Start
2016-04
Primary completion
2026-12
Completion
2026-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Trimethaphan Small molecule 0.5 mg Intravenous
Subject Trimethaphan Small molecule 4 mg Intravenous