drugset / Trial / NCT02727387
Protocol for the Treatment of Metastatic Ewing Sarcoma
NaSingle-groupOpen-labelTreatment
Summary
Study for the treatment of metastatic Ewing sarcoma with high doses chemotherapy, radiotherapy and maintenance therapy.
Timeline
- Start
- 2009-06-01
- Primary completion
- 2022-04-29
- Completion
- 2022-04-29
Publications
- Background Picci P, Bohling T, Bacci G, Ferrari S, Sangiorgi L, Mercuri M, Ruggieri P, Manfrini M, Ferraro A, Casadei R, Benassi MS, Mancini AF, Rosito P, Cazzola A, Barbieri E, Tienghi A, Brach del Prever A, Comandone A, Bacchini P, Bertoni F. Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing's sarcoma of the extremities. J Clin Oncol. 1997 Apr;15(4):1553-9. doi: 10.1200/JCO.1997.15.4.1553.
- Background Gardner SL, Carreras J, Boudreau C, Camitta BM, Adams RH, Chen AR, Davies SM, Edwards JR, Grovas AC, Hale GA, Lazarus HM, Arora M, Stiff PJ, Eapen M. Myeloablative therapy with autologous stem cell rescue for patients with Ewing sarcoma. Bone Marrow Transplant. 2008 May;41(10):867-72. doi: 10.1038/bmt.2008.2. Epub 2008 Feb 4.
- Background Paulussen M, Ahrens S, Burdach S, Craft A, Dockhorn-Dworniczak B, Dunst J, Frohlich B, Winkelmann W, Zoubek A, Jurgens H. Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies. Ann Oncol. 1998 Mar;9(3):275-81. doi: 10.1023/a:1008208511815.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ADM | Unknown | 80 mg/m2 | — |
| Subject | ADM | Unknown | 90 mg/m2 | — |
| Subject | Busulfan | Small molecule | 0.8 mg/kg | — |
| Subject | Busulfan | Small molecule | 1.2 mg/kg | — |
| Subject | CYC | Unknown | 35 mg/m2 | Oral |
| Subject | CYC | Unknown | 50 mg/m2 | Oral |
| Subject | CYC | Unknown | 1.2 g | Oral |
| Subject | CYC | Unknown | 4 g | Oral |
| Subject | ETO | Unknown | 300 mg/m2 | — |
| Subject | ETO | Unknown | 600 mg/m2 | — |
| Subject | IFO | Unknown | 9 g | — |
| Subject | Irinotecan | Small molecule | 250 mg/m2 | — |
| Subject | Melphalan | Small molecule | 140 mg/m2 | — |
| Subject | Temozolomide | Small molecule | 500 mg/m2 | — |
| Subject | VIN | Unknown | 1.4 mg/m2 | — |