drugset / Trial / NCT02734238

Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery

Phase 4 Completed 53 enrolled Pennington Biomedical Research Center Defence Research and Development Canada · collab MyoSyntax · collab United States Army Research Institute of Environmental Medicine · collab United States Department of Defense · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The objective of this study is to determine whether maintaining a eugonadal state, during severe, sustained energy deficit, attenuates physiological decrements, particularly the loss of lean body mass.

Timeline

Start: 2016-04
Primary completion: 2017-12
Completion: 2017-12

Publications

Background Pasiakos SM, Margolis LM, Orr JS. Optimized dietary strategies to protect skeletal muscle mass during periods of unavoidable energy deficit. FASEB J. 2015 Apr;29(4):1136-42. doi: 10.1096/fj.14-266890. Epub 2014 Dec 30.
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Background Carbone JW, McClung JP, Pasiakos SM. Skeletal muscle responses to negative energy balance: effects of dietary protein. Adv Nutr. 2012 Mar 1;3(2):119-26. doi: 10.3945/an.111.001792.
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Background Roy TC. Diagnoses and mechanisms of musculoskeletal injuries in an infantry brigade combat team deployed to Afghanistan evaluated by the brigade physical therapist. Mil Med. 2011 Aug;176(8):903-8. doi: 10.7205/milmed-d-11-00006.
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Background Pasiakos SM, Austin KG, Lieberman HR, Askew EW. Efficacy and safety of protein supplements for U.S. Armed Forces personnel: consensus statement. J Nutr. 2013 Nov;143(11):1811S-1814S. doi: 10.3945/jn.113.176859. Epub 2013 Sep 11.
Background Margolis LM, Murphy NE, Martini S, Spitz MG, Thrane I, McGraw SM, Blatny JM, Castellani JW, Rood JC, Young AJ, Montain SJ, Gundersen Y, Pasiakos SM. Effects of winter military training on energy balance, whole-body protein balance, muscle damage, soreness, and physical performance. Appl Physiol Nutr Metab. 2014 Dec;39(12):1395-401. doi: 10.1139/apnm-2014-0212.
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Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Testosterone Enanthate	Small molecule	200 mg	Intramuscular

Indications

No indication recorded.