Drugs / Testosterone Enanthate
last change Jun 2026 re-read 2 minutes ago

Testosterone Enanthate

Small molecule targets AR via activation

Developed for
hypogonadism, male · castration-resistant prostate carcinoma · hypogonadism · HIV wasting syndrome · muscular atrophy · prostate cancer · spinal cord injury · facioscapulohumeral muscular dystrophy
+4 more · hypogonadotropic hypogonadism · hypoproteinemia, hypercatabolic · prostate adenocarcinoma · chronic obstructive pulmonary disease
Investigated by
Antares Pharma Inc. · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · United States Department of Defense · National Cancer Institute (NCI) · University of Florida · VA Office of Research and Development
+32 more · AstraZeneca · Australian and New Zealand Urogenital and Prostate Cancer Trials Group · Bayer · Brigham and Women's Hospital · Brooks Rehabilitation · Central Hospital, Nancy, France · Charles Drew University of Medicine and Science · Clarus Therapeutics, Inc. · Defence Research and Development Canada · Endo USA Inc., a Keenova Therapeutics Company · Enhanced Emirates Limited · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · GlaxoSmithKline · Gulhane School of Medicine · HMRI · Halozyme Therapeutics · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Merck Sharp & Dohme LLC · MyoSyntax · National Institute of Allergy and Infectious Diseases (NIAID) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Institute on Aging (NIA) · North Florida Foundation for Research and Education · North Florida/South Georgia Veterans Health System · Pennington Biomedical Research Center · St Vincent's Hospital, Sydney · The George Institute · The University of Texas Medical Branch, Galveston · United States Army Research Institute of Environmental Medicine · University of Rochester · University of Washington · VA Eastern Colorado Health Care System

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (2) US (FDA) DELATESTRYL 1979-08-02 – 1980-02-01 fda.gov
Approved US (FDA) DELATESTRYL 1953-12-24 fda.gov

Trials 27 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 13 trials
Phase 1 NCT03123913 Dec 2017 → Mar 2022 facioscapulohumeral muscular dystrophy University of Rochester Completed No outcome recorded
Phase 1 NCT02233751 Sep → Oct 2014 hypogonadism Antares Pharma Inc. Completed No outcome recorded
Phase 1 NCT01962454 May 2014 → Mar 2015 hypoproteinemia, hypercatabolic GlaxoSmithKline Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT01887418 Sep 2013 → Jan 2014 hypogonadism Antares Pharma Inc. Completed No outcome recorded
Phase 213 trials
Phase 2 NCT06594926 Aug 2024 → Dec 2026 expected prostate cancer Australian and New Zealand Urogenital and Prostate Cancer Trials Group Recruiting No outcome recorded
Phase 2 NCT04460872 Jan 2021 → Jan 2026 overdue hypogonadism, male, male reproductive system disorder, movement disorder, spinal cord injury North Florida Foundation for Research and Education Recruiting No outcome recorded
Phase 2 NCT04363164 Aug 2020 → Jul 2027 expected castration-resistant prostate carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting No outcome recorded
Phase 2 NCT03516812 Aug 2018 → Mar 2021 castration-resistant prostate carcinoma, prostate adenocarcinoma University of Washington Completed No outcome recorded
Phase 2 NCT03522064 Jul 2018 → Sep 2026 expected castration-resistant prostate carcinoma St Vincent's Hospital, Sydney Recruiting No outcome recorded
Phase 2 NCT02248701 Apr 2017 → Aug 2021 hypogonadism, male reproductive system disorder, spinal cord injury VA Office of Research and Development Terminated No outcome recorded
Phase 2 NCT02777242 Jun → Aug 2016 hypogonadism, male Antares Pharma Inc. Completed No outcome recorded
Phase 2 NCT02286921 Jan 2015 → Oct 2018 castration-resistant prostate carcinoma Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Completed No outcome recorded
Phase 2 NCT02090114 Aug 2014 → Nov 2021 prostate cancer Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Completed No outcome recorded
Phase 2 NCT00695110 Jun → Dec 2008 hypogonadism, male Clarus Therapeutics, Inc. Completed No outcome recorded
Phase 35 trials
Phase 3 NCT06689085 Mar 2025 → Mar 2028 expected hypogonadism, male Halozyme Therapeutics Recruiting No outcome recorded
Phase 3 NCT02504541 Jul 2015 → Jun 2016 hypogonadism, male Antares Pharma Inc. Completed No outcome recorded
Phase 3 NCT02159469 Jul 2014 → Feb 2015 hypogonadism, male Antares Pharma Inc. Completed No outcome recorded
Phase 3 NCT01275365 May 2011 → Jan 2017 Brigham and Women's Hospital Completed No outcome recorded
Phase 3 NCT00070733 Aug 2003 → Jun 2005 sexual disorder Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Unknown No outcome recorded
Phase 43 trials
Phase 4 NCT02734238 Apr 2016 → Dec 2017 Pennington Biomedical Research Center Completed No outcome recorded
Phase 4 NCT01417364 Jan → Dec 2016 muscular atrophy The University of Texas Medical Branch, Galveston Withdrawn No outcome recorded
Phase 4 NCT01601327 Jan 2008 → Mar 2012 hypogonadotropic hypogonadism Gulhane School of Medicine Completed No outcome recorded
Phase not applicable2 trials
NCT07568574 Mar 2026 → May 2028 expected Enhanced Emirates Limited Enrolling by invitation No outcome recorded
NCT04971447 Aug 2022 → Sep 2023 Central Hospital, Nancy, France Unknown No outcome recorded
Also used as a comparator or background therapy in 8 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00878995 Comparator Jun 2009 → Jun 2014 hypoproteinemia, hypercatabolic, squamous cell carcinoma The University of Texas Medical Branch, Galveston Completed No outcome recorded
Phase 1 NCT01017458 Comparator Jun 2007 → Aug 2008 Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1/21 trial
Phase 1/2 NCT00399165 Comparator Nov 2006 → May 2007 University of Washington Completed No outcome recorded
Phase 21 trial
Phase 2 NCT02697188 Comparator Nov 2007 → Apr 2008 hypogonadism Clarus Therapeutics, Inc. Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT03674320 Comparator Dec 2021 → Aug 2024 chronic obstructive pulmonary disease The University of Texas Medical Branch, Galveston Withdrawn No outcome recorded
Phase 2/3 NCT00161304 Comparator Apr 2003 → Aug 2004 Leonard S. Marks, M.D. Completed No outcome recorded
Phase 31 trial
Phase 3 NCT04026880 Comparator Jan 2021 → Jan 2022 Brigham and Women's Hospital Withdrawn No outcome recorded
Phase 41 trial
Phase 4 NCT00493987 Comparator Nov 2002 → Dec 2009 Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Completed No outcome recorded

Evidence & citations 16 cited values

Every value below carries the sentence it was read from. 38 sources stand behind the page.

FieldValueCited text
Known as Testosterone Enanthate “Pharmacokinetic Study of Testosterone EnanthateNCT01887418
34

testosterone enanthateNCT04971447

NCT00493987

NCT00878995

NCT02248701

NCT00695110

NCT00260143

NCT01417364

NCT00475501

NCT01275365

NCT02233751

NCT01962454

NCT03674320

NCT07568574

NCT03516812

NCT02734238

NCT00399165

NCT00161304

NCT03522064

NCT01017458

NCT04460872

NCT00070733

NCT03123913

NCT04026880

NCT06594926

NCT02504541

NCT00001079

NCT02286921

NCT04363164

NCT02090114

NCT06689085

NCT02159469

NCT01601327

NCT02777242

NCT02697188

Known as Androtardyl ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as delatestryl delatestrylNCT02248701
Known as NSC-17591 ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as Primoteston depot ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as TEST “The objective of this study was to determine the effects of weekly testosterone enanthate (TEST; 200 mg·wk -1 ) injections on energy expenditure, energy substrate oxidation,...” PMID 36563086 Nov 2022
Known as Testosterone enantate ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as Testosterone enanthate ciii ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as Testosterone enanthate component of ditate-ds ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as Testosteroni enantas ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as Xyosted ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Known as Xyosted (autoinjector) ChEMBL registry synonym — accepted as the source's own label CHEMBL1200335
Action Activate “Androgen Receptor agonist” CHEMBL1200335
Modality Small molecule CHEMBL1200335
Route Intramuscular “testosterone enanthate or matching placebo intramuscularly” PMID 17105798 Nov 2006
Target AR “Androgen Receptor agonist” CHEMBL1200335