drugset / Trial / NCT02739035
MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty
RandomizedParallel-groupOpen-labelTreatment
Summary
Compare the outcome following manipulation under anesthesia for stiffness in a randomized controlled fashion with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Outcomes will include pain, range of motion, as well as subjective outcome scores.
Timeline
- Start
- 2016-04
- Primary completion
- 2022-12
- Completion
- 2022-12
Outcome
Missed primary endpoint
registry analysis (superiority test); MUA Alone vs MUA With Dexamethasone and Celecoxib; p = 0.23; t-test, 2 sided NCT02739035 ↗
registry analysis (superiority test); MUA Alone vs MUA With Dexamethasone and Celecoxib; p = 0.81; t-test, 2 sided NCT02739035 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Celecoxib | Other / unclassified | 200 mg | Oral |
| Subject | Dexamethasone | Small molecule | 8 mg | Intravenous |
Indications
No indication recorded.