Nitrous Oxide Versus Intravenous Sedation for Anesthesia

Completed 39 enrolled University of New Mexico Society of Family Planning · collab University of Colorado, Denver · collab

RandomizedParallel-groupTriple-blindOther

Summary

This study is a multi-site, double-blinded, randomized, non-inferiority clinical trial of inhaled nitrous oxide with oxygen (N2O/O2) versus intravenous (IV) sedation, with fentanyl and midazolam, for pain management in adult women having a pregnancy termination procedure between 12 and 16 weeks gestational age.

Timeline

Start: 2016-07
Primary completion: 2017-05
Completion: 2017-05

Publications

Thaxton L, Pitotti J, Espey E, Teal S, Sheeder J, Singh RH. Nitrous Oxide Compared With Intravenous Sedation for Second-Trimester Abortion: A Randomized Controlled Trial. Obstet Gynecol. 2018 Nov;132(5):1192-1197. doi: 10.1097/AOG.0000000000002915.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nitrous Oxide	Other / unclassified	70 %	Inhaled

Indications

No indication recorded.