drugset / Trial / NCT02762123
A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe Substrates
Non-randomizedParallel-groupOpen-labelBasic science
Summary
The study is being conducted to assess the effect of BMS-986142 on the single-dose PK parameters of montelukast, flurbiprofen, omeprazole, midazolam, and digoxin, probe drugs for (cytochome P450) CYP2C8, CYP2C9, CYP2C19, CYP3A4, and P-glycoprotein (P-gp), respectively.
Timeline
- Start
- 2016-05
- Primary completion
- 2016-08
- Completion
- 2016-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | BMS-986142 | Small molecule | 200 mg | Oral |
| Subject | BMS-986142 | Small molecule | 350 mg | Oral |
| Subject | Digoxin | Other / unclassified | — | — |
| Subject | Flurbiprofen | Small molecule | — | — |
| Subject | Midazolam | Small molecule | — | — |
| Subject | Montelukast | Other / unclassified | — | — |
| Subject | Omeprazole | Other / unclassified | — | — |