drugset / Trial / NCT02774564
Pharmacokinetic-pharmacodynamic Interaction Between BIA 3-202 and Levodopa/Carbidopa
RandomizedCrossoverDouble-blindTreatment
Summary
The purpose of this study is to the effect of three single oral doses of nebicapone (50 mg, 100 mg and 200 mg) on the levodopa pharmacokinetics when administered in combination with a single-dose of controlled release levodopa 200 mg/carbidopa 50 mg (Sinemet CR 200/50).
Timeline
- Start
- 2005-09
- Primary completion
- 2005-11
- Completion
- 2005-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Levodopa | Small molecule | 200 mg | — |
| Subject | Nebicapone | Small molecule | 50 mg | Oral |
| Subject | Nebicapone | Small molecule | 100 mg | Oral |
| Subject | Nebicapone | Small molecule | 200 mg | Oral |
| Background | Carbidopa | Unknown | 50 mg | — |