Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia

Phase 4 Completed 64 enrolled Guangzhou General Hospital of Guangzhou Military Command

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).

Timeline

Start: 2016-01
Primary completion: 2016-06
Completion: 2016-07

Publications

Background Chen Z, Shao DH, Hang LH. Effects of dexmedetomidine on performance of bispectral index as an indicator of loss of consciousness during propofol administration. Swiss Med Wkly. 2013 Mar 14;143:w13762. doi: 10.4414/smw.2013.13762. eCollection 2013.
Background Hannivoort LN, Eleveld DJ, Proost JH, Reyntjens KM, Absalom AR, Vereecke HE, Struys MM. Development of an Optimized Pharmacokinetic Model of Dexmedetomidine Using Target-controlled Infusion in Healthy Volunteers. Anesthesiology. 2015 Aug;123(2):357-67. doi: 10.1097/ALN.0000000000000740.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.4 ng/ml	—
Subject	Dexmedetomidine	Other / unclassified	0.6 ng/ml	—
Subject	Dexmedetomidine	Other / unclassified	0.8 ng/ml	—
Subject	Propofol	Small molecule	1 ug/ml	Intravenous

Indications

No indication recorded.