Effects of Intravenous Lidocaine During Sedation for Colonoscopy.

Phase 4 Completed 40 enrolled University of Liege

RandomizedParallel-groupDouble-blindSupportive care

Summary

This study assesses the benefits of continuous intravenous lidocaine administration during sedation for colonoscopy. Sedation will consist of propofol infusion titrated to provide adequate working conditions to the gastroenterologist. Patients will be randomly allocated into two groups: lidocaine infusion (bolus of 1.5 mg/kg followed by a continuous infusion of 4 mg/kg/h) or the same volume of placebo (normal saline)

Timeline

Start: 2016-03
Primary completion: 2016-09
Completion: 2016-10

Publications

Forster C, Vanhaudenhuyse A, Gast P, Louis E, Hick G, Brichant JF, Joris J. Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study. Br J Anaesth. 2018 Nov;121(5):1059-1064. doi: 10.1016/j.bja.2018.06.019. Epub 2018 Aug 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Lidocaine	Other / unclassified	4 mg/kg	Intravenous

Indications

No indication recorded.