drugset / Trial / NCT02789969

Pain Medications in Children Undergoing Strabismus Surgery

NCT02789969

Unknown 128 enrolled St. Louis Children's Hospital
RandomizedParallel-groupSingle-blindTreatment

Summary

Every year over 1,000 children undergo eye muscle surgery provided by physicians at this institution. For many of these children this is not and will not be the only surgical procedure for eye muscle correction. All of these children will experience differing degrees of postoperative pain. The pain associated with strabismus surgery is due to the manipulation in the conjunctival area and further handling of Tenon's capsule, sclera and the stretching of the eye muscle . Research has demonstrated that repeated painful procedures result in increased anxiety and increased pain. Previous studies have demonstrated that children experiencing preoperative anxiety are more likely to have increased postoperative pain . This increased preoperative anxiety may also contribute to sleep difficulties and increased analgesic consumption. Depending on the age of the child, different methods are used to reduce anxiety such as distraction, child life services, or anti-anxiolytic agents. In addition to pain, children undergoing strabismus surgery frequently experience postoperative nausea and vomiting (PONV).This increased incidence of nausea and vomiting is thought to be related to the use of opiates for pain control. Short acting opiates are used preferentially at this hospital in the belief that this reduces recovery issues of sedation and PONV. Preliminary data, however, suggests no difference in recovery outcomes for fentanyl versus hydromorphone. The purpose of this study is to investigate the optimal analgesia to create a standardized approach for pain management in pediatric patients undergoing surgery for strabismus.

Timeline

Start
2016-04
Primary completion
2017-03
Completion
2017-04

Publications

Drugs

EvaluationDrugModalityDoseRoute
Subject Fentanyl Other / unclassified 1.5 ug/kg Intravenous
Subject Hydromorphone Other / unclassified 15 ug/kg Intravenous

Indications

No indication recorded.