Induction of Migraine Aura With Sildenafil

Phase 0 Completed 16 enrolled Herlev Hospital

RandomizedCrossoverQuadruple-blindBasic science

Summary

In a double blind placebo-controlled cross-over study the effect of Sildenafil on aura and migraine headache induction is tested in patient with migraine with aura.

Timeline

Start: 2015-06
Primary completion: 2021-02
Completion: 2021-08

Outcome

Met primary endpoint

paper Aura symptoms were induced in three patients (19%) after sildenafil and none after placebo (P < 0.001). PMID 35332812 ↗

Publications

Butt JH, S Eddelien H, Kruuse C. The headache and aura-inducing effects of sildenafil in patients with migraine with aura. Cephalalgia. 2022 Sep;42(10):984-992. doi: 10.1177/03331024221088998. Epub 2022 Mar 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sildenafil	Unknown	100 mg	Oral