Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure

Summary

The study evaluates the pharmacokinetics of metformin in heart failure patients in acute and chronic state in relation to metformin transporter genotypes. Participants have heart failure and type 2 diabetes treated with metformin. Hypothesis: Primary: The renal clearance of metformin is decreased in acute state of congestive heart failure compared with chronic state. Secondary: Metformin trough values in HF patients are influenced by polymorphisms in transporter genes relevant to the pharmacokinetics of metformin.

Timeline

Start

2016-01-11

Primary completion

2018-04-30

Completion

2018-04-30

Drugs

Indications