Combined Letrozole and Clomid in Women With Infertility and PCOS

Summary

This study evaluates the addition of clomid to letrozole for the treatment of infertility in women with polycystic ovary syndrome. Half of the participants will receive letrozole and clomid in combination, while the other half will receive letrozole alone.

Timeline

Start

2016-08

Primary completion

2018-05

Completion

2019-02

Outcome

Met primary endpoint

registry analysis (superiority test); Letrozole vs Letrozole + Clomiphene; p = 0.007; Rate ratio 1.80 (95% CI 1.18 to 2.75); Chi-squared, Corrected NCT02802865 ↗

paper Women who received the combination of letrozole and CC had a statistically higher ovulation rate compared with those who received letrozole alone (27 of 35 women [77%] vs. 15 of 35 women [43%]). PMID 30683591 ↗

Publications

• Mejia RB, Summers KM, Kresowik JD, Van Voorhis BJ. A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome. Fertil Steril. 2019 Mar;111(3):571-578.e1. doi: 10.1016/j.fertnstert.2018.11.030. Epub 2019 Jan 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clomiphene Citrate	Other / unclassified	50 mg	Oral
Subject	Letrozole	Other / unclassified	2.5 mg	Oral

Indications