Influence of Dexmedetomidine or Propofol on ICU Delirium

Phase 4 Terminated 37 enrolled University Hospital, Basel, Switzerland

RandomizedParallel-groupOpen-labelTreatment

Summary

In this randomized study, the investigators aim to test the hypothesis that the reinstitution of a normal circadian rhythm by continuous infusions of dexmedetomidine compared to propofol between 8pm and 6am after diagnosis of hyperactive or mixed delirium, decreases the duration of delirium. The infusions might have to be repeated several times to achieve resolution of delirium.

Timeline

Start: 2019-03-01
Primary completion: 2022-03-03
Completion: 2023-02-11

Outcome

Outcome not reported

Stopped (Enrollment): “insufficient recruitment over a long period”

Publications

Hollinger A, Ledergerber K, von Felten S, Sutter R, Ruegg S, Gantner L, Zimmermann S, Blum A, Steiner LA, Marsch S, Siegemund M. Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial. BMJ Open. 2017 Jul 13;7(7):e015783. doi: 10.1136/bmjopen-2016-015783.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	—	—
Comparator	Propofol	Small molecule	—	—