drugset / Trial / NCT02813785

A Study of Atezolizumab Compared With Docetaxel in Non-Small Cell Lung Cancer (NSCLC) After Failure With Platinum-Containing Chemotherapy

NCT02813785

Phase 3 Completed 565 enrolled Hoffmann-La Roche
RandomizedParallel-groupOpen-labelTreatment

Summary

This Phase III, multicenter, open-label, randomized, controlled study is designed to evaluate the efficacy and safety of the anti-programmed death-ligand 1 (PD-L1) antibody atezolizumab compared with docetaxel in participants with locally advanced or metastatic NSCLC who have progressed during or following a platinum-containing regimen. Treatment may continue until disease progression, loss of clinical benefit, or unacceptable toxicity.

Timeline

Start
2016-07-01
Primary completion
2019-08-01
Completion
2022-12-27

Drugs

EvaluationDrugModalityDoseRoute
Subject Atezolizumab Monoclonal antibody 1200 mg Intravenous
Comparator Docetaxel Small molecule 75 mg/m2 Intravenous