Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery

Phase 4 Completed 84 enrolled Duke University

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine if the infusion of the local anesthetic ropivacaine (a numbing medicine) and the non-steroidal anti-inflammatory drug ketorolac (a pain killer similar to ibuprofen) through a catheter placed along the cesarean delivery incision, will reduce the pain experienced after cesarean section and need for narcotic pain medicine.

Timeline

Start: 2016-11
Primary completion: 2019-03
Completion: 2019-09

Outcome

Missed primary endpoint

paper There was no significant difference between the groups in the primary outcome of pain score with movement at 24 hours (difference in median score 0, 95% CI -1 to 2, P=.94). PMID 31923061 ↗

Publications

Barney EZ, Pedro CD, Gamez BH, Fuller ME, Dominguez JE, Habib AS. Ropivacaine and Ketorolac Wound Infusion for Post-Cesarean Delivery Analgesia: A Randomized Controlled Trial. Obstet Gynecol. 2020 Feb;135(2):427-435. doi: 10.1097/AOG.0000000000003601.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketorolac	Other / unclassified	30 mg	Other
Subject	Ropivacaine	Other / unclassified	440 mg	Other

Indications

No indication recorded.