Influence of Gender on Interaction of Propofol and Dexmedetomidine

Phase 4 Completed 120 enrolled Guangzhou General Hospital of Guangzhou Military Command

RandomizedCrossoverDouble-blindTreatment

Summary

The purpose of this study is to determine the effect of gender on pharmacodynamic interaction of propofol and dexmedetomidine, exploring the effect of gender on propofol unconsciousness median effective concentration with different dose dexmedetomidine.

Timeline

Start: 2016-08
Primary completion: 2016-12
Completion: 2016-12

Publications

Background Kodaka M, Johansen JW, Sebel PS. The influence of gender on loss of consciousness with sevoflurane or propofol. Anesth Analg. 2005 Aug;101(2):377-381. doi: 10.1213/01.ANE.0000154534.71371.4F.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexmedetomidine	Other / unclassified	0.4 ng/ml	—
Subject	Dexmedetomidine	Other / unclassified	0.6 ng/ml	—
Subject	Dexmedetomidine	Other / unclassified	0.8 ng/ml	—
Subject	Propofol	Small molecule	1 ug/ml	—

Indications

No indication recorded.