The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled Study

Completed 92 enrolled Seoul National University Hospital

RandomizedParallel-groupQuadruple-blindPrevention

Summary

High-dose remifentanil infused intraoperative ironically results in postoperative hyperalgesia. Ultra-low dose nalxone is demonstrated to prevent these opioid-induced hyperalgesia in animal model. In this clinical trial in patients undergoing general anesthesia with remifentanil, we evaluate the effects of ultra-low-dose naloxone on remifentanil-induced hyperalgesia

Timeline

Start: 2014-11
Primary completion: 2015-04
Completion: 2015-04

Publications

Koo CH, Yoon S, Kim BR, Cho YJ, Kim TK, Jeon Y, Seo JH. Intraoperative naloxone reduces remifentanil-induced postoperative hyperalgesia but not pain: a randomized controlled trial. Br J Anaesth. 2017 Dec 1;119(6):1161-1168. doi: 10.1093/bja/aex253.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Naloxone	Small molecule	0.8 ng/ml	—
Subject	Remifentanil	Small molecule	1 ng/ml	—
Subject	Remifentanil	Small molecule	4 ng/ml	—

Indications

No indication recorded.