The Effect of Ultra-low-dose Naloxone on Remifentanil-induced Postoperative Hyperalgesia - A Randomized Controlled Study

Summary

High-dose remifentanil infused intraoperative ironically results in postoperative hyperalgesia. Ultra-low dose nalxone is demonstrated to prevent these opioid-induced hyperalgesia in animal model. In this clinical trial in patients undergoing general anesthesia with remifentanil, we evaluate the effects of ultra-low-dose naloxone on remifentanil-induced hyperalgesia

Timeline

Start

2014-11

Primary completion

2015-04

Completion

2015-04

Outcome

Met primary endpoint

paper significantly lower in the high-remifentanil group (n=31) than in the high-remifentanil with naloxone (n=30) and the low-remifentanil (n=30) groups PMID 29029049 ↗

paper 3.63 (3.22-3.84) vs 3.84 (3.76-4.00) vs 3.80 (3.69-4.08), P=0.011 PMID 29029049 ↗

Publications

• Koo CH, Yoon S, Kim BR, Cho YJ, Kim TK, Jeon Y, Seo JH. Intraoperative naloxone reduces remifentanil-induced postoperative hyperalgesia but not pain: a randomized controlled trial. Br J Anaesth. 2017 Dec 1;119(6):1161-1168. doi: 10.1093/bja/aex253.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Naloxone	Small molecule	0.8 ng/ml	—
Subject	Remifentanil	Small molecule	1 ng/ml	—
Subject	Remifentanil	Small molecule	4 ng/ml	—

Indications

No indication recorded.