drugset / Trial / NCT02860806
Safety, Tolerability, Pharmacokinetic and Absolute Bioavailability Study of JNJ-63623872 Administered as an Intravenous Infusion and a 600-Milligram (mg) Oral Dose in Healthy Adults
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of this study is to characterize the single-dose pharmacokinetic (PK) of single escalating intravenous (IV) doses of JNJ-63623872 administered as a continuous infusion; to evaluate the safety and tolerability of single escalating IV doses of JNJ-63623872 administered as a continuous infusion; to characterize the single-dose PK of JNJ-63623872 of one selected dose administered as a continuous IV infusion at various durations and to characterize the single- and repeat-dose PK of JNJ-63623872 administered as a continuous infusion.
Timeline
- Start
- 2016-08-08
- Primary completion
- 2017-06-06
- Completion
- 2017-06-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Pimodivir | Small molecule | 100 mg | Intravenous |
| Subject | Pimodivir | Small molecule | 200 mg | Intravenous |
| Subject | Pimodivir | Small molecule | 300 mg | Intravenous |
| Subject | Pimodivir | Small molecule | 600 mg | Intravenous |
Indications
No indication recorded.