Drugs / Pimodivir

Trials 18 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 113 trials
Phase 1 NCT03947814 Jul 2019 → Sep 2020 chronic renal failure syndrome Janssen-Cilag International NV Terminated No outcome recorded
Phase 1 NCT03816631 May 2019 → Apr 2020 Janssen-Cilag International NV Completed No outcome recorded
Phase 1 NCT03768609 Dec 2018 → Mar 2019 Janssen-Cilag International NV Completed No outcome recorded
Phase 1 NCT03023852 Feb → Apr 2017 Janssen-Cilag International NV Completed No outcome recorded
Phase 1 NCT02860806 Aug 2016 → Jun 2017 Janssen-Cilag International NV Completed No outcome recorded
Phase 1 NCT02888327 Jul 2016 → May 2017 influenza Alios Biopharma Inc. Completed No outcome recorded
Phase 1 NCT02658825 Jan → Apr 2016 Janssen Research & Development, LLC Completed No outcome recorded
Phase 1 NCT02652650 Dec 2015 → Jun 2016 Janssen Research & Development, LLC Completed No outcome recorded
Phase 1 NCT02659735 Dec 2015 → Apr 2016 influenza Janssen Research & Development, LLC Completed No outcome recorded
Phase 1 NCT02595268 Nov 2015 → Jan 2016 Janssen Research & Development, LLC Completed No outcome recorded
Phase 22 trials
Phase 2 NCT02532283 Dec 2015 → Feb 2017 influenza Janssen Research & Development, LLC Completed No outcome recorded
Phase 2 NCT01561807 Mar → Oct 2012 influenza Vertex Pharmaceuticals Incorporated Completed No outcome recorded
Phase 32 trials
Phase 3 NCT03381196 Jan 2018 → May 2020 influenza Janssen Research & Development, LLC Terminated No outcome recorded
Phase 3 NCT03376321 Jan 2018 → Mar 2020 influenza Janssen Research & Development, LLC Terminated No outcome recorded
Phase not stated1 trial
NCT03834376 Janssen Research & Development, LLC No longer available No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT02342249 Comparator Dec 2014 → May 2016 influenza Janssen Research & Development, LLC Completed No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2014-06-18 Vertex Pharmaceuticals Incorporated Vertex Licenses VX-787 to Janssen Pharmaceuticals for the Treatment of Influenza vrtx.com
2013-03-04 Vertex Pharmaceuticals Incorporated VX-787 Showed Significant Antiviral Activity and Reduced the Severity and Duration of Influenza Symptoms in Phase 2 Challenge Study vrtx.com

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 21 sources stand behind the page.

FieldValueCited text
Known as Pimodivir “Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial.” PMID 30428049 Mar 2019
7

“A Phase 2 Study of Pimodivir (JNJ-63623872) in Combination With Oseltamivir in” PMID 32604406 Aug 2022

NCT03834376

NCT03816631

NCT03376321

NCT03768609

NCT03947814

NCT03381196

Known as JNJ - 63623872 - ZCD ChEMBL registry synonym — accepted as the source's own label CHEMBL3318007
Known as JNJ-872 “The purpose of this study is to evaluate the effect of steady-state concentrations of JNJ-63623872 on the single-dose pharmacokinetics of pitavastatin in healthy participants....” NCT02595268
Known as JNJ-872 HYDROCHLORIDE HEMIHYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL3318007
Known as JNJ63623872 “The purpose of this study is to assess the rate and extent of absorption of JNJ63623872 following administration of a single oral dose of 2\*300 milligram (mg) given as 2...” NCT03023852
10

NCT02888327

NCT02860806

NCT02595268

NCT02658825

NCT02532283

NCT02448004

NCT02659735

NCT03023852

NCT02418559

NCT02652650

Known as PIMODIVIR HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL3318007
Known as VX-787 “This open-label, four group, fixed-sequence study will evaluate the safety and pharmacokinetic interaction of AL-794 on oseltamivir, JNJ-63623872 (formerly VX-787) and probes...” NCT02888327
2

NCT01561807

NCT02262715

Known as Vx-787 anhydrous base ChEMBL registry synonym — accepted as the source's own label CHEMBL3318007
Action Inhibit “Pimodivir, a first-in-class inhibitor of influenza virus polymerase basic protein 2” PMID 30428049 Mar 2019
Modality Small molecule CHEMBL3318007
Route Oral “taken orally for 5 days” NCT01561807