IV Dexamethasone for Prolongation of Peripheral Nerve Block

Phase 3 Completed 18 enrolled University Health Network, Toronto

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This is a volunteer study examining the effect of different doses of IV dexamethasone on prolongation of median nerve block in the forearm.

Timeline

Start: 2016-11-12
Primary completion: 2018-02-20
Completion: 2018-02-20

Outcome

Missed primary endpoint

paper The primary outcome, time to recovery of pinprick sensation, was similar between volunteers receiving saline or i.v. dexamethasone, regardless of dose (P=0.99). PMID 31711605 ↗

Publications

Short A, El-Boghdadly K, Clarke H, Komaba T, Jin R, Chin KJ, Chan V. Effect of intravenous dexamethasone on the anaesthetic characteristics of peripheral nerve block: a double-blind, randomised controlled, dose-response volunteer study. Br J Anaesth. 2020 Jan;124(1):92-100. doi: 10.1016/j.bja.2019.08.029. Epub 2019 Nov 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	2 mg	Intravenous
Subject	Dexamethasone	Small molecule	4 mg	Intravenous
Subject	Dexamethasone	Small molecule	8 mg	Intravenous

Indications

No indication recorded.