Management of Tunneled Catheter Thrombosis in Hemodialysis Patients: Prospective Study From Qatar
Summary
Goal of the study: A- To find out the best protocol for catheter lock solution to decrease the prevalence of catheter thrombosis 1. \- The time to first episode of catheter thrombosis lead to catheter change. 2. \- Number of acute episode of thrombosis that interrupt dialysis 3. \- Median Survival life of the catheter in both groups after adjusting it to the outcome. B- Specific Objective: To evaluate the cost effectiveness by measure 1- Amount of r-TPA used in each group to treatment acute catheter thrombosis 2- Number of catheter exchange in both group 3- Hospitalization days related to catheter malfunctioning or CRI in each group 4- Type and days of antibiotics 5- Cost of the treatment in each group c- Secondary Objective: To correlate the result of two catheters lock solution protocols with the published data using r-TPA instead of heparin once week as compared with heparin 3 times per week as a locking solution.
Timeline
- Start
- 2013-11
- Primary completion
- 2015-08
- Completion
- 2015-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Heparin | Other / unclassified | 500 unknown | Other |
| Subject | Urokinase | Protein / enzyme biologic | 25000 iu | Other |
| Background | citrate | Unknown | 4 % | Other |
| Comparator | taurolidine | Small molecule | 1.35 % | Other |
Indications
No indication recorded.