drugset

drugset / Trial / NCT02874144

Anti-Inflammatory Agent in Sinusitis

NCT02874144 ↗

Phase 2 Completed 43 enrolled Northwestern University

RandomizedParallel-groupDouble-blindTreatment

Summary

To evaluate the efficacy of an anti-inflammatory agent compared with placebo in relieving signs and symptoms of disease in patients with sinusitis.

Timeline

Start: 2016-06-20
Primary completion: 2020-01-07
Completion: 2020-08-10

Publications

Price CPE, Guo A, Stevens WW, Cousens L, Vu TT, Suh LA, Erickson KA, Conley D, Grammer LC, Kern RC, Tan BK, Kato A, Schleimer RP, Smith SS, Welch KC, Peters AT. Efficacy of an oral CRTH2 antagonist (AZD1981) in the treatment of chronic rhinosinusitis with nasal polyps in adults: A randomized controlled clinical trial. Clin Exp Allergy. 2022 Jul;52(7):859-867. doi: 10.1111/cea.14158. Epub 2022 May 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	AZD1981	Small molecule	40 mg	—
Background	Fluticasone propionate	Other / unclassified	—	Intranasal
Background	Mometasone furoate	Other / unclassified	—	Intranasal

Indications