Drugs / AZD1981
last change May 2022 re-read 2 minutes ago

AZD1981

Small molecule targets PTGDR2 via inhibition

Developed for
asthma · chronic obstructive pulmonary disease · chronic idiopathic urticaria · nasal cavity polyp
Investigated by
AstraZeneca · Johns Hopkins University · Northwestern University

Trials 16 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 110 trials
Phase 1 NCT01311635 Apr → May 2011 AstraZeneca Completed No outcome recorded
Phase 1 NCT01254461 Feb → Apr 2011 AstraZeneca Completed No outcome recorded
Phase 1 NCT01265641 Jan → Apr 2011 asthma AstraZeneca Completed No outcome recorded
Phase 1 NCT01199341 Oct → Dec 2010 AstraZeneca Completed No outcome recorded
Phase 1 NCT01196689 Oct 2010 → Feb 2011 asthma AstraZeneca Completed No outcome recorded
Phase 1 NCT01110525 May → Oct 2010 AstraZeneca Completed No outcome recorded
Phase 1 NCT01058447 Feb → Mar 2010 AstraZeneca Completed No outcome recorded
Phase 1 NCT00918398 Jun → Jul 2009 AstraZeneca Completed No outcome recorded
Phase 1 NCT00859352 Mar → Apr 2009 AstraZeneca Completed No outcome recorded
Phase 1 NCT00698282 Aug → Oct 2008 AstraZeneca Completed No outcome recorded
Phase 26 trials
Phase 2 NCT02874144 Jun 2016 → Jan 2020 nasal cavity polyp Northwestern University Completed No outcome recorded
Phase 2 NCT02031679 Jan 2014 → Jan 2016 chronic idiopathic urticaria Johns Hopkins University Completed No outcome recorded
Phase 2 NCT01197794 Oct 2010 → Feb 2012 asthma AstraZeneca Completed No outcome recorded
Phase 2 NCT00766415 Nov 2008 → Jun 2009 chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded
Phase 2 NCT00758589 Sep 2008 → Jul 2009 asthma AstraZeneca Completed No outcome recorded
Phase 2 NCT00690482 May → Dec 2008 chronic obstructive pulmonary disease AstraZeneca Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 18 sources stand behind the page.

FieldValueCited text
Known as AZD1981 AZD1981 is a selective antagonist of chemoattractant receptor-homologous molecule expressed on T helper type 2 and other type 2 cells, including innate lymphoid cells type 2,...” PMID 35524339 May 2022
15

NCT00698282

NCT01110525

NCT01254461

NCT01197794

NCT02031679

NCT01058447

NCT01311635

NCT01199341

NCT01196689

NCT01265641

NCT00918398

NCT00758589

NCT00766415

NCT00690482

NCT00859352

Action Inhibit “a potent, specific antagonist of the CRTh2 receptor” PMID 29765200 May 2018
1

“G protein-coupled receptor 44 antagonist” CHEMBL1914489

Modality Small molecule CHEMBL1914489
Route Oral “AZD1981 Oral tablet, twice daily” NCT00690482
Target PTGDR2 “G protein-coupled receptor 44 antagonist” CHEMBL1914489