drugset / Trial / NCT02874430
Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer
Phase 2
Terminated
29 enrolled
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NaSingle-groupOpen-labelTreatment
Summary
This phase II trial studies how well metformin hydrochloride works together with doxycycline in treating patients with localized breast or uterine cancer. Metformin hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Doxycycline may stop the growth of bacteria by keeping them from making proteins and minimized the toxic side effects of anti-cancer therapy. It is not yet known whether giving metformin hydrochloride together with doxycycline may be a better way in treating patients with localized breast or uterine cancer.
Timeline
- Start
- 2016-06-08
- Primary completion
- 2020-12-11
- Completion
- 2020-12-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Doxycycline | Small molecule | — | Oral |
| Subject | Metformin | Small molecule | — | Oral |