Efficacy and Safety of Hourly Titrated Misoprostol Versus Vaginal Dinoprostone and Misoprostol for Cervical Ripening and Labor Induction

Phase 4 Unknown 372 enrolled Oihane Lapuente Ocamica

RandomizedParallel-groupOpen-labelTreatment

Summary

This study evaluates the efficacy and safety of the administration of oral misoprostol versus vaginal dinoprostone and vaginal misoprostol for cervical ripening and labor induction.

Timeline

Start: 2016-09
Primary completion: 2020-09
Completion: 2020-09

Publications

Lapuente-Ocamica O, Ugarte L, Lopez-Picado A, Sanchez-Refoyo F, Lasa IL, Echevarria O, Alvarez-Sala J, Farinas A, Bilbao I, Barbero L, Vicarregui J, Hernanz Chaves R, Paz Corral D, Lopez-Lopez JA. Efficacy and safety of administering oral misoprostol by titration compared to vaginal misoprostol and dinoprostone for cervical ripening and induction of labour: study protocol for a randomised clinical trial. BMC Pregnancy Childbirth. 2019 Jan 8;19(1):14. doi: 10.1186/s12884-018-2132-3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dinoprostone	Other / unclassified	10 mg	Intravenous
Comparator	Misoprostol	Other / unclassified	25 ug	Intravenous
Comparator	Misoprostol	Other / unclassified	—	Oral

Indications

No indication recorded.