Perineural Versus Systemic Dexamethasone to Prolong Regional Anesthesia in Front Foot Surgery

Summary

Both perineural and systemic dexamethasone administration allows an increase in analgesic duration of regional anesthesia. There is a lack of data to determine wich route allows a longer analgesic effect. This study aims to determine wether perineural dexamethasone allows a longer analgesic duration than systemic route in combination with regional anesthesia (Ropivacaine 0.375%) for front foot surgery.

Timeline

Start

2016-11-22

Primary completion

2017-05-23

Completion

2017-05-23

Outcome

Missed primary endpoint

paper Time period to first rescue analgesia with tramadol was similar in the IVDex group and the PNDex group. PMID 29630032 ↗

paper Duration of analgesia was 23.2 (9.5) hours in the IVDex group and 19 (8.2) hours in the PNDex group (P = 0.4). PMID 29630032 ↗

Publications

• Marty P, Rontes O, Chassery C, Vuillaume C, Basset B, Merouani M, Marquis C, Bataille B, Chaubard M, Mailles MC, Ferre F, Delbos A. Perineural Versus Systemic Dexamethasone in Front-Foot Surgery Under Ankle Block: A Randomized Double-Blind Study. Reg Anesth Pain Med. 2018 Oct;43(7):732-737. doi: 10.1097/AAP.0000000000000769.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dexamethasone	Small molecule	4 mg	Other
Subject	Dexamethasone	Small molecule	10 mg	Other

Indications

No indication recorded.