Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features

Summary

NSAIDs, specifically cyclo-oxygenase (COX) inhibitors, are known to increase blood pressure over time in non-pregnant adults, but the effect of COX-inhibitors on blood pressure in the setting of preeclampsia have not been well studied. This study aims to assess the effect of avoiding COX-inhibitors on postpartum blood pressure control among women diagnosed with preeclampsia with severe features. Eligible women will be randomized to receive either acetaminophen or ibuprofen for postpartum pain control. Both agents are first line therapies for pain control although ibuprofen has better pain control than acetaminophen. The primary outcome will be duration of postpartum severe-range hypertension.

Timeline

Start

2016-09

Primary completion

2017-11-07

Completion

2018-01-10

Outcome

Missed primary endpoint

registry analysis (superiority test); Acetaminophen vs Ibuprofen; p = 0.3; maxim NCT02911701 ↗

Drugs

Indications