drugset / Trial / NCT02931591
Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children
Unknown
24 enrolled
Cambridge University Hospitals NHS Foundation Trust
Birmingham Women's and Children's NHS Foundation Trust · collabRigshospitalet, Denmark · collabThe National Children's Hospital, Tallaght · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This study is aimed to determine if Metformin treatment in children born small for gestational age (SGA) who are being treated with Growth Hormone (GH) for short stature improves the response to GH by producing greater concentrations of Insulin-like growth factor -1 (IGF-1) in the blood.
Timeline
- Start
- 2016-11
- Primary completion
- 2019-11
- Completion
- 2020-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Metformin | Small molecule | — | Oral |
| Comparator | Somatropin | Protein / enzyme biologic | — | — |