drugset / Trial / NCT02933593
Changes in Central Arterial Pressure When Comparing ACOG Hypertensive Urgency Protocols
Withdrawn
St. Louis University
RandomizedSingle-groupOpen-labelTreatment
Summary
The investigators plan to monitor the central blood pressure in women with severely elevated blood pressures (160/110) in pregnancy in the acute setting. Currently ACOG recommends 3 different options for blood pressure control, however no one has studied how these medications affect the central pressures, only peripheral blood pressure.
Timeline
- Start
- 2016-08
- Primary completion
- 2017-01
- Completion
- 2017-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydralazine | Small molecule | 5 mg | Intravenous |
| Comparator | Hydralazine | Small molecule | 10 mg | Intravenous |
| Comparator | Labetalol | Small molecule | 20 mg | Intravenous |
| Comparator | Labetalol | Small molecule | 40 mg | Intravenous |
| Comparator | Labetalol | Small molecule | 80 mg | Intravenous |
| Comparator | Nifedipine | Other / unclassified | 10 mg | Oral |
| Comparator | Nifedipine | Other / unclassified | 20 mg | Oral |