drugset / Trial / NCT02939573
A Randomized Multicenter Study for Isolated Skin Vasculitis
Phase 2
Recruiting
90 enrolled
University of Pennsylvania
National Center for Advancing Translational Sciences (NCATS) · collabNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) · collabOffice of Rare Diseases (ORD) · collab
RandomizedCrossoverOpen-labelTreatment
Summary
Multi-center sequential multiple assignment randomized trial comparing the effectiveness of three different standard of care treatment options for patients with isolated skin vasculitis.
Timeline
- Start
- 2017-01-01
- Primary completion
- 2028-12-31
- Completion
- 2028-12-31
Publications
- Hahn D, Hodson EM, Craig JC. Interventions for preventing and treating kidney disease in IgA vasculitis. Cochrane Database Syst Rev. 2023 Feb 28;2(2):CD005128. doi: 10.1002/14651858.CD005128.pub4.
- Micheletti RG, Pagnoux C, Tamura RN, Grayson PC, McAlear CA, Borchin R, Krischer JP, Merkel PA; Vasculitis Clinical Research Consortium. Protocol for a randomized multicenter study for isolated skin vasculitis (ARAMIS) comparing the efficacy of three drugs: azathioprine, colchicine, and dapsone. Trials. 2020 Apr 28;21(1):362. doi: 10.1186/s13063-020-04285-3.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Azathioprine | Small molecule | 2 mg/kg | — |
| Subject | Colchicine | Small molecule | 0.6 mg | — |
| Subject | Dapsone | Small molecule | 150 mg | — |