drugset / Trial / NCT02940301

Ibrutinib and Nivolumab in Treating Patients With Relapsed or Refractory Classical Hodgkin Lymphoma

NCT02940301 ↗

Phase 2 Active not recruiting 18 enrolled Ohio State University Comprehensive Cancer Center
NaSingle-groupOpen-labelTreatment

Summary

This phase II trial studies how well ibrutinib and nivolumab work in treating patients with classical Hodgkin lymphoma that has come back or has not responded to treatment. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as nivolumab, may block cancer growth in different ways by targeting certain cells. Giving ibrutinib and nivolumab may work better in treating patients with classical Hodgkin lymphoma.

Timeline

Start
2016-12-20
Primary completion
2026-08-15
Completion
2026-08-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Ibrutinib Small molecule 560 mg —
Subject Nivolumab Monoclonal antibody 3 mg/kg Intravenous