Nivolumab
Monoclonal antibody targets PDCD1
Regulatory milestones approvals, filings & regulatory actions · 47 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansions (45) | US (FDA) | OPDIVO | — | 2015-09-30 – 2026-03-20 | fda.gov ↗ |
| Approved | EU (EMA) | Opdivo | — | 2015-06-19 | europa.eu ↗ |
| Approved | US (FDA) | OPDIVO | — | 2014-12-22 | fda.gov ↗ |
Trials 1,493 · started per year
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 029 trials | ||||||
| Phase 0 | NCT07319195 | Apr 2026 → Apr 2028 expected | breast cancer | Jennifer Zhang | Recruiting | No outcome recorded |
| Phase 0 | NCT07210632 | Mar 2026 → Mar 2030 expected | brain cancer, malignant glioma | Eben Rosenthal | Recruiting | No outcome recorded |
| Phase 0 | NCT07328087 | Feb 2026 → Dec 2030 expected | colorectal cancer | Biogenea Pharmaceuticals Ltd. | Recruiting | No outcome recorded |
| Phase 0 | NCT06204614 | Jun 2024 → Jul 2028 expected | infiltrating bladder urothelial carcinoma | Brigham and Women's Hospital | Enrolling by invitation | No outcome recorded |
| Phase 0 | NCT05704933 | Jun 2023 → Jun 2024 | metastatic malignant neoplasm in the brain, metastatic melanoma | H. Lee Moffitt Cancer Center and Research Institute | Completed | No outcome recorded |
| Phase 0 | NCT05188118 | Feb 2023 → Sep 2026 expected | renal cell carcinoma | Icahn School of Medicine at Mount Sinai | Recruiting | No outcome recorded |
| Phase 0 | NCT05498792 | Nov 2022 → Mar 2027 expected | melanoma | Fox Chase Cancer Center | Recruiting | No outcome recorded |
| Phase 0 | NCT04272333 | Oct 2021 → Mar 2022 | head and neck squamous cell carcinoma | Presage Biosciences | Terminated | No outcome recorded |
| Phase 0 | NCT04891718 | Sep 2021 → Jun 2022 | cancer | Presage Biosciences | Withdrawn | No outcome recorded |
| Phase 0 | NCT04741997 | May 2021 → Jul 2026 overdue | metastatic melanoma | H. Lee Moffitt Cancer Center and Research Institute | Recruiting | No outcome recorded |
| Phase 0 | NCT05482451 | Mar 2021 → Feb 2025 overdue | — | China Medical University Hospital | Active not recruiting | No outcome recorded |
| Phase 0 | NCT04581382 | Dec 2020 → Oct 2024 | melanoma | Mayo Clinic | Completed | No outcome recorded |
| Phase 0 | NCT04223648 | Aug 2020 → Feb 2022 | melanoma | Yale University | Withdrawn | No outcome recorded |
| Phase 0 | NCT03519308 | Jul 2020 → Apr 2022 | malignant pancreatic neoplasm | Abramson Cancer Center at Penn Medicine | Terminated | No outcome recorded |
| Phase 0 | NCT04134325 | Sep 2019 → Apr 2025 overdue | Hodgkins lymphoma | UNC Lineberger Comprehensive Cancer Center | Active not recruiting | No outcome recorded |
| Phase 0 | NCT03970252 | Jul 2019 → May 2024 | pancreatic ductal adenocarcinoma | Jonsson Comprehensive Cancer Center | Completed | No outcome recorded |
| Phase 0 | NCT03812562 | Feb 2019 → Oct 2023 | hepatocellular carcinoma | Northwestern University | Terminated | No outcome recorded |
| Phase 0 | NCT03575598 | Aug 2018 → Feb 2020 | oral cavity squamous cell carcinoma | University Health Network, Toronto | Completed | No outcome recorded |
| Phase 0 | NCT03463408 | Jul 2018 → Aug 2026 overdue | sarcoma | University of Rochester | Active not recruiting | No outcome recorded |
| Phase 0 | NCT03543969 | Jun 2018 → Dec 2024 overdue | cutaneous melanoma, skin carcinoma | H. Lee Moffitt Cancer Center and Research Institute | Active not recruiting | No outcome recorded |
| Phase 0 | NCT03311958 | May 2018 → Jan 2024 | diffuse large B-cell lymphoma | Fox Chase Cancer Center | Completed | No outcome recorded |
| Phase 0 | NCT03316274 | May 2018 → Jun 2021 | AIDS, Kaposi's sarcoma | University of California, San Francisco | Completed | No outcome recorded |
| Phase 0 | NCT03526185 | Feb 2018 → Dec 2020 | metastatic melanoma | Yale University | Terminated | No outcome recorded |
| Phase 0 | NCT03224871 | Aug 2017 → Jan 2020 | non-small cell lung carcinoma | University of California, Davis | Completed | No outcome recorded |
| Phase 0 | NCT03238365 | Aug 2017 → Jul 2019 | head and neck carcinoma, laryngeal disorder | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | Completed | No outcome recorded |
| Phase 0 | NCT03162731 | May 2017 → Sep 2020 | head and neck carcinoma, laryngeal disorder | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | Completed | No outcome recorded |
| Phase 0 | NCT03143270 | Apr 2017 → Apr 2027 expected | liver cancer | Memorial Sloan Kettering Cancer Center | Active not recruiting | No outcome recorded |
| Phase 0 | NCT02652455 | Mar 2016 → Aug 2020 | cutaneous melanoma | H. Lee Moffitt Cancer Center and Research Institute | Completed | No outcome recorded |
| Phase 0 | NCT02210117 | Nov 2014 → Dec 2026 expected | clear cell renal carcinoma | M.D. Anderson Cancer Center | Active not recruiting | No outcome recorded |
| Phase 1309 trials | ||||||
| Phase 1 | NCT07430202 | Aug 2026 → Aug 2030 expected | fibrolamellar hepatocellular carcinoma | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT07460765 | Jul 2026 → Apr 2030 expected | oral cavity squamous cell carcinoma | Vanderbilt-Ingram Cancer Center | Recruiting | No outcome recorded |
| Phase 1 | NCT07501117 | Jun 2026 → Jun 2029 expected | uveal melanoma | Inge Marie Svane | Recruiting | No outcome recorded |
| Phase 1 | NCT07476326 | Jun 2026 → Aug 2027 expected | melanoma | Biocon Biologics UK Ltd | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT07664176 | Jun 2026 → Dec 2030 expected | atypical teratoid rhabdoid tumor, brain cancer, ependymoma, malignant glioma +1 | Children's National Research Institute | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT07075120 | Apr 2026 → Aug 2027 expected | hepatocellular carcinoma | University of Hawaii | Recruiting | No outcome recorded |
| Phase 1 | NCT07401875 | Mar 2026 → Nov 2027 expected | kidney cancer | M.D. Anderson Cancer Center | Recruiting | No outcome recorded |
| Phase 1 | NCT07090148 | Mar 2026 → Oct 2030 expected | metastatic prostate carcinoma | University of Wisconsin, Madison | Recruiting | No outcome recorded |
| Phase 1 | NCT07653503 | Jan 2026 → Dec 2027 expected | cervical carcinoma | University Medical Center Groningen | Recruiting | No outcome recorded |
| Phase 1 | NCT06968988 | Jan 2026 → Feb 2029 expected | soft tissue sarcoma | Washington University School of Medicine | Recruiting | No outcome recorded |
| Show all 309 trials opens the full record — a long page | ||||||
| Phase 1/2275 trials | ||||||
| Phase 1/2 | NCT07631325 | Oct 2026 → Jul 2028 expected | cutaneous melanoma | John Kirkwood | Not yet recruiting | No outcome recorded |
| Phase 1/2 | NCT07679841 | Sep 2026 → Sep 2029 expected | vulvar squamous cell carcinoma | Centre Leon Berard | Not yet recruiting | No outcome recorded |
| Phase 1/2 | NCT06639607 | Aug 2026 → Aug 2031 | ependymoma, medulloblastoma | Washington University School of Medicine | Suspended | No outcome recorded |
| Phase 1/2 | NCT07281924 | Jul 2026 → Dec 2030 expected | metastatic melanoma | University of Wisconsin, Madison | Recruiting | No outcome recorded |
| Phase 1/2 | NCT07482059 | Feb → Jun 2026 overdue | hepatocellular carcinoma | West China Hospital | Recruiting | No outcome recorded |
| Phase 1/2 | NCT07276373 | Jan → Sep 2026 expected | neoplasm | Corcept Therapeutics | Recruiting | No outcome recorded |
| Phase 1/2 | NCT07190027 | Nov 2025 overdue | non-small cell lung carcinoma | First Affiliated Hospital of Wenzhou Medical University | Not yet recruiting | No outcome recorded |
| Phase 1/2 | NCT06866262 | Aug 2025 → Aug 2031 expected | clear cell renal carcinoma, sarcomatoid renal cell carcinoma | University of Michigan Rogel Cancer Center | Recruiting | No outcome recorded |
| Phase 1/2 | NCT07121374 | Jul 2025 → Jun 2028 expected | pleural epithelioid mesothelioma | University Hospital, Antwerp | Recruiting | No outcome recorded |
| Phase 1/2 | NCT06047015 | Jul 2025 → Dec 2027 expected | metastasis from malignant tumor of colon | University of Saskatchewan | Not yet recruiting | No outcome recorded |
| Show all 275 trials opens the full record — a long page | ||||||
| Phase 2712 trials | ||||||
| Phase 2 | NCT07644312 | Mar 2027 → Mar 2033 expected | DNA repair disease, diffuse intrinsic pontine glioma, grade III glioma | Nationwide Children's Hospital | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT07603856 | Dec 2026 → Jun 2030 expected | non-small cell lung carcinoma | University of Chicago | Recruiting | No outcome recorded |
| Phase 2 | NCT07689175 | Oct 2026 → Oct 2031 expected | hepatocellular carcinoma | University of Texas Southwestern Medical Center | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT07551583 | Oct 2026 → Dec 2030 expected | Hodgkins lymphoma | M.D. Anderson Cancer Center | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT07576725 | Sep 2026 → Aug 2029 expected | Hodgkins lymphoma, Kaposi's sarcoma, acral lentiginous melanoma, cervical cancer +10 | Fred Hutchinson Cancer Center | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06319196 | Aug 2026 → Feb 2027 expected | cutaneous melanoma, mucosal melanoma | University Health Network, Toronto | Recruiting | No outcome recorded |
| Phase 2 | NCT07694986 | Aug 2026 → Aug 2029 expected | breast cancer, neoplastic meningitis | H. Lee Moffitt Cancer Center and Research Institute | Recruiting | No outcome recorded |
| Phase 2 | NCT07492680 | Jul 2026 → Aug 2028 expected | cancer | Bristol-Myers Squibb | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT07546812 | Jul 2026 → Jan 2030 expected | Her2-receptor negative breast cancer, esophageal adenocarcinoma, gastric adenocarcinoma, gastroesophageal junction adenocarcinoma | Gilead Sciences | Recruiting | No outcome recorded |
| Phase 2 | NCT07645118 | Jul 2026 → Dec 2028 expected | — | Dr. Te Vuong | Not yet recruiting | No outcome recorded |
| Show all 712 trials opens the full record — a long page | ||||||
| Phase 2/320 trials | ||||||
| Phase 2/3 | NCT07572123 | Dec 2026 → Mar 2029 expected | classic Hodgkin lymphoma | National Cancer Institute (NCI) | Not yet recruiting | No outcome recorded |
| Phase 2/3 | NCT07000253 | Apr 2026 → Jun 2031 expected | carcinoma of esophagus, gastric adenocarcinoma | Academic Medical Center - University of Amsterdam | Recruiting | No outcome recorded |
| Phase 2/3 | NCT07221149 | Mar 2026 → Nov 2030 expected | gastroesophageal adenocarcinoma | Bristol-Myers Squibb | Recruiting | No outcome recorded |
| Phase 2/3 | NCT06203600 | Jun 2024 → Oct 2027 expected | esophageal adenocarcinoma, gastric adenocarcinoma, gastroesophageal junction adenocarcinoma | National Cancer Institute (NCI) | Recruiting | No outcome recorded |
| Phase 2/3 | NCT05987241 | Feb 2024 → Sep 2030 expected | infiltrating bladder urothelial carcinoma, infiltrating renal pelvis/ureter urothelial carcinoma, urethra transitional cell carcinoma | National Cancer Institute (NCI) | Recruiting | No outcome recorded |
| Phase 2/3 | NCT05595447 | Oct 2022 → Oct 2025 overdue | Hodgkins lymphoma | Hospital Regional de Alta Especialidad del Bajio | Recruiting | No outcome recorded |
| Phase 2/3 | NCT05213312 | Jun → Nov 2022 | esophageal squamous cell carcinoma | Shanghai Zhongshan Hospital | Unknown | No outcome recorded |
| Phase 2/3 | NCT04901988 | Nov 2021 → Jan 2023 | cutaneous melanoma | The Christie NHS Foundation Trust | Terminated | No outcome recorded |
| Phase 2/3 | NCT04695977 | Feb 2021 → Jul 2024 | metastatic melanoma | Regeneron Pharmaceuticals | Terminated | No outcome recorded |
| Phase 2/3 | NCT04396860 | Sep 2020 → Jan 2023 | gliosarcoma | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 2/3 | NCT04044651 | Oct 2019 → Mar 2021 | hepatocellular carcinoma | Shi Ming | Withdrawn | No outcome recorded |
| Phase 2/3 | NCT03952585 | Oct 2019 → Mar 2024 overdue | basaloid squamous cell carcinoma, oropharynx squamous cell carcinoma, papillary squamous carcinoma | National Cancer Institute (NCI) | Active not recruiting | No outcome recorded |
| Phase 2/3 | NCT04268888 | May 2019 → Aug 2025 | hepatocellular carcinoma | The Clatterbridge Cancer Centre NHS Foundation Trust | Suspended | No outcome recorded |
| Phase 2/3 | NCT03604991 | May 2019 → Dec 2026 | esophageal adenocarcinoma, gastroesophageal junction adenocarcinoma | National Cancer Institute (NCI) | Suspended | No outcome recorded |
| Phase 2/3 | NCT03879122 | Feb 2019 → Jul 2023 | metastatic prostate carcinoma | Spanish Oncology Genito-Urinary Group | Unknown | No outcome recorded |
| Phase 2/3 | NCT03470922 | Apr 2018 → Jan 2021 overdue | melanoma | Bristol-Myers Squibb | Active not recruiting | No outcome recorded |
| Phase 2/3 | NCT03414983 | Feb 2018 → Feb 2021 | colorectal cancer | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 2/3 | NCT03092674 | Feb 2018 → Aug 2023 | acute myeloid leukemia, myelodysplastic syndrome | National Cancer Institute (NCI) | Completed | No outcome recorded |
| Phase 2/3 | NCT03366272 | Dec 2017 → Jan 2025 | non-Hodgkin lymphoma | Saarland University | Completed | No outcome recorded |
| Phase 2/3 | NCT02746796 | Mar 2016 → Jan 2020 | gastric cancer | Ono Pharmaceutical Co., Ltd. | Completed | No outcome recorded |
| Phase 3116 trials | ||||||
| Phase 3 | NCT07166406 | Feb 2026 → Mar 2029 expected | hepatocellular carcinoma | NRG Oncology | Recruiting | No outcome recorded |
| Phase 3 | NCT07431281 | Feb 2026 → Aug 2029 expected | esophageal cancer, gastric cancer, gastroesophageal junction adenocarcinoma | AstraZeneca | Recruiting | No outcome recorded |
| Phase 3 | NCT07174453 | Oct 2025 → Oct 2027 expected | — | University of Kansas Medical Center | Recruiting | No outcome recorded |
| Phase 3 | NCT07050043 | May 2025 → Dec 2030 expected | non-small cell lung carcinoma | Dr Arvindran A/L Alaga | Recruiting | No outcome recorded |
| Phase 3 | NCT06646276 | Feb 2025 → Apr 2028 expected | small cell lung carcinoma | Bristol-Myers Squibb | Recruiting | No outcome recorded |
| Phase 3 | NCT06488482 | Dec 2024 → Sep 2030 expected | melanoma | Uppsala University | Recruiting | No outcome recorded |
| Phase 3 | NCT06632327 | Dec 2024 → Apr 2029 expected | non-small cell lung carcinoma | Alliance for Clinical Trials in Oncology | Recruiting | No outcome recorded |
| Phase 3 | NCT06490536 | Oct 2024 → Mar 2026 overdue | colorectal cancer | IFOM ETS - The AIRC Institute of Molecular Oncology | Recruiting | No outcome recorded |
| Phase 3 | NCT06561386 | Oct 2024 → Jul 2030 expected | non-small cell lung carcinoma | Bristol-Myers Squibb | Recruiting | No outcome recorded |
| Phase 3 | NCT06264180 | Jul 2024 → Sep 2030 expected | melanoma | Replimune, Inc. | Recruiting | No outcome recorded |
| Show all 116 trials opens the full record — a long page | ||||||
| Phase 411 trials | ||||||
| Phase 4 | NCT07459543 | Nov 2026 → May 2029 expected | metastatic melanoma | Bristol-Myers Squibb | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07574047 | Sep 2026 → Jun 2030 expected | melanoma | Swiss Cancer Institute | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT06934057 | May 2025 → Apr 2028 expected | renal cell carcinoma | Gustave Roussy, Cancer Campus, Grand Paris | Recruiting | No outcome recorded |
| Phase 4 | NCT06031233 | Sep 2023 → Jul 2028 expected | — | Isala | Recruiting | No outcome recorded |
| Phase 4 | NCT06116461 | Jan 2022 → Oct 2024 | melanoma | Erasmus Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT04513522 | Dec 2020 → Jan 2024 | kidney neoplasm | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 4 | NCT04331626 | Apr 2020 → Dec 2022 | non-small cell lung carcinoma | Henan Cancer Hospital | Unknown | No outcome recorded |
| Phase 4 | NCT03444766 | Mar 2018 → Jul 2019 | kidney cancer, non-small cell lung carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 4 | NCT02982954 | Jan 2017 → May 2020 | renal cell carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 4 | NCT02869789 | Oct 2016 → May 2022 | lung cancer | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 4 | NCT02596035 | Jan 2016 → Mar 2018 | renal cell carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase not applicable18 trials | ||||||
| — | NCT07233668 | Dec 2025 → Oct 2028 expected | renal cell carcinoma | Seoul National University Hospital | Not yet recruiting | No outcome recorded |
| — | NCT06341478 | Mar 2024 → Mar 2026 overdue | urinary bladder cancer | IRCCS San Raffaele | Recruiting | No outcome recorded |
| — | NCT06158919 | Nov 2023 → Nov 2024 overdue | gastroesophageal junction adenocarcinoma | Fudan University | Recruiting | No outcome recorded |
| — | NCT05652673 | Feb 2023 → Dec 2025 overdue | metastatic melanoma, poisoning | Erasmus Medical Center | Recruiting | No outcome recorded |
| — | NCT04845139 | Jul → Oct 2022 | central nervous system non-hodgkin lymphoma | Second Affiliated Hospital, School of Medicine, Zhejiang University | Unknown | No outcome recorded |
| — | NCT07422779 | Mar 2022 → Mar 2027 expected | metastatic melanoma, skin cancer | Institute of Oncology Ljubljana | Recruiting | No outcome recorded |
| — | NCT07428252 | Mar 2022 → Mar 2024 overdue | metastatic melanoma | Institute of Oncology Ljubljana | Active not recruiting | No outcome recorded |
| — | NCT07053202 | Oct 2021 → Nov 2022 | hepatocellular carcinoma | The First Hospital of Hebei Medical University | Completed | No outcome recorded |
| — | NCT05001360 | Oct 2021 → Oct 2023 | esophageal adenocarcinoma, gastric adenocarcinoma, gastroesophageal junction adenocarcinoma | Fujian Cancer Hospital | Withdrawn | No outcome recorded |
| — | NCT04801966 | Sep 2021 → Dec 2022 | cancer | Peter MacCallum Cancer Centre, Australia | Terminated | No outcome recorded |
| — | NCT05053295 | Jul 2021 → Jul 2023 | adenocarcinoma, gastroesophageal cancer | Gangnam Severance Hospital | Unknown | No outcome recorded |
| — | NCT05745233 | Jan 2021 → Dec 2026 expected | peritoneal neoplasm | China Medical University Hospital | Enrolling by invitation | No outcome recorded |
| — | NCT04603248 | Dec 2020 → Mar 2026 | head and neck squamous cell carcinoma | Yonsei University | Completed | No outcome recorded |
| — | NCT04256213 | Jul 2020 → Aug 2021 | cervical cancer | ARCAGY/ GINECO GROUP | Completed | No outcome recorded |
| — | NCT03035890 | Jan 2017 → Jun 2022 | non-small cell lung carcinoma | West Virginia University | Completed | No outcome recorded |
| — | NCT02833233 | Jun 2016 → Jun 2024 | breast cancer | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| — | NCT05063058 | Jan 2016 → Nov 2019 | melanoma | Charite University, Berlin, Germany | Completed | No outcome recorded |
| — | NCT02194738 | Sep 2014 → Sep 2026 expected | non-small cell lung carcinoma | National Cancer Institute (NCI) | Active not recruiting | No outcome recorded |
| Phase not stated3 trials | ||||||
| — | NCT02142218 | Jun 2014 → May 2018 | melanoma | Bristol-Myers Squibb | No longer available | No outcome recorded |
| — | NCT02186249 | — | melanoma | Bristol-Myers Squibb | No longer available | No outcome recorded |
| — | NCT02475382 | — | non-small cell squamous lung carcinoma | Bristol-Myers Squibb | No longer available | No outcome recorded |
Also used as a comparator or background therapy in 244 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 04 trials | ||||||
| Phase 0 | NCT07017816 Background | Dec 2025 → May 2028 expected | atypical teratoid rhabdoid tumor, ependymoma, malignant glioma, medulloblastoma +1 | Children's National Research Institute | Recruiting | No outcome recorded |
| Phase 0 | NCT05358938 Background | Jun 2022 → Oct 2024 overdue | cutaneous melanoma, cutaneous neuroendocrine carcinoma, skin squamous cell carcinoma | H. Lee Moffitt Cancer Center and Research Institute | Active not recruiting | No outcome recorded |
| Phase 0 | NCT04570683 Comparator | Jan 2020 → Sep 2021 | allergic disease, basal cell carcinoma | Bispebjerg Hospital | Unknown | No outcome recorded |
| Phase 0 | NCT03371992 Background | Mar 2018 → Dec 2020 | non-small cell lung carcinoma | Nilogen Oncosystems | Unknown | No outcome recorded |
| Phase 165 trials | ||||||
| Phase 1 | NCT07176975 Background | Aug 2027 → Dec 2028 | cancer | Boehringer Ingelheim | Suspended | No outcome recorded |
| Phase 1 | NCT07518043 Comparator | Jun 2026 → Aug 2027 expected | gastroesophageal cancer, melanoma, urothelial carcinoma | Shanghai Henlius Biotech | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT07444619 Background | Jun 2026 → Dec 2031 expected | soft tissue sarcoma | M.D. Anderson Cancer Center | Recruiting | No outcome recorded |
| Phase 1 | NCT07532902 Background | Apr 2026 → Apr 2029 expected | diffused pleural mesothelioma, gastroesophageal cancer, urothelial carcinoma | Memorial Sloan Kettering Cancer Center | Recruiting | No outcome recorded |
| Phase 1 | NCT07187869 Background | Mar 2026 → Apr 2027 expected | clear cell renal carcinoma | M.D. Anderson Cancer Center | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT07128680 Background | Mar 2026 → Aug 2028 expected | clear cell renal carcinoma, sarcomatoid renal cell carcinoma | City of Hope Medical Center | Recruiting | No outcome recorded |
| Phase 1 | NCT07404332 Background | Feb 2026 → Feb 2028 expected | cancer, metastatic neoplasm | Mohammed Milhem | Recruiting | No outcome recorded |
| Phase 1 | NCT07176650 Background | Nov 2025 → Dec 2026 expected | hepatocellular carcinoma | Shanghai Henlius Biotech | Recruiting | No outcome recorded |
| Phase 1 | NCT07334119 Background | Nov 2025 → Jan 2027 expected | carcinoma | Myeloid Therapeutics | Recruiting | No outcome recorded |
| Phase 1 | NCT05717140 Background | Oct 2025 → Jan 2026 | cutaneous melanoma, metastatic malignant neoplasm, metastatic melanoma | Mayo Clinic | Withdrawn | No outcome recorded |
| Phase 1 | NCT06889493 Background | May 2025 → Jun 2030 expected | neuroendocrine carcinoma | Peter Hosein, MD | Recruiting | No outcome recorded |
| Phase 1 | NCT06800339 Background | Apr 2025 → Mar 2028 expected | non-small cell lung carcinoma | University of Maryland, Baltimore | Recruiting | No outcome recorded |
| Phase 1 | NCT05629546 Background | Nov 2024 → Feb 2029 expected | metastatic melanoma | Washington University School of Medicine | Recruiting | No outcome recorded |
| Phase 1 | NCT06302426 Background | Jul 2024 → Oct 2026 expected | neoplasm | Inimmune Corporation | Recruiting | No outcome recorded |
| Phase 1 | NCT06377111 Background | Jun 2024 → Aug 2027 expected | cutaneous melanoma | University Health Network, Toronto | Active not recruiting | No outcome recorded |
| Phase 1 | NCT05802056 Background | Nov 2023 → Apr 2027 expected | gastric adenocarcinoma, gastroesophageal junction adenocarcinoma, peritoneum cancer | Mayo Clinic | Active not recruiting | No outcome recorded |
| Phase 1 | NCT05867121 Background | Oct 2023 → Mar 2026 | gastric cancer, non-small cell lung carcinoma, pancreatic ductal adenocarcinoma | Genentech, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT06112808 Comparator | May 2023 → Jan 2024 overdue | melanoma | Biocad | Active not recruiting | No outcome recorded |
| Phase 1 | NCT05704985 Background | Apr 2023 → Jul 2025 overdue | colorectal cancer, female reproductive organ cancer, head and neck cancer, kidney cancer +3 | DEKA Biosciences | Active not recruiting | No outcome recorded |
| Phase 1 | NCT05681780 Background | Mar 2023 → Jun 2026 overdue | non-small cell lung carcinoma | H. Lee Moffitt Cancer Center and Research Institute | Recruiting | No outcome recorded |
| Phase 1 | NCT05472506 Background | Mar → Apr 2023 | head and neck squamous cell carcinoma, malignant tumor of neck | Ikena Oncology | Withdrawn | No outcome recorded |
| Phase 1 | NCT05254184 Background | Nov 2022 → Apr 2027 expected | non-small cell lung carcinoma | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Recruiting | No outcome recorded |
| Phase 1 | NCT05608148 Background | Oct 2022 → Aug 2027 expected | childhood malignant neoplasm, neuroblastoma | Kyushu University | Recruiting | No outcome recorded |
| Phase 1 | NCT05375084 Background | Oct 2022 → Apr 2024 | non-small cell lung carcinoma | Navire Pharma Inc., a BridgeBio company | Terminated | No outcome recorded |
| Phase 1 | NCT05169957 Background | Aug 2022 → Jun 2023 | cutaneous melanoma, metastatic melanoma, mucosal melanoma, ocular melanoma | University of Michigan Rogel Cancer Center | Completed | No outcome recorded |
| Phase 1 | NCT05303493 Background | Jun 2022 → Jul 2025 | melanoma, non-small cell lung carcinoma | University of Montreal Hospital Centre (CHUM) | Completed | No outcome recorded |
| Phase 1 | NCT05098210 Background | Jun 2022 → Nov 2027 expected | acral lentiginous melanoma, female breast carcinoma, hormone receptor-positive breast cancer, malignant conjunctival melanoma +3 | Fred Hutchinson Cancer Center | Recruiting | No outcome recorded |
| Phase 1 | NCT05354102 Background | May 2022 → May 2024 | melanoma, non-small cell lung carcinoma, renal cell carcinoma | Biomica Ltd. | Unknown | No outcome recorded |
| Phase 1 | NCT05076760 Background | Apr 2022 → Feb 2027 expected | cutaneous neuroendocrine carcinoma, head and neck cancer, malignant pancreatic neoplasm, melanoma +4 | Memgen, LLC | Recruiting | No outcome recorded |
| Phase 1 | NCT05108623 Background | Jan 2022 → Jan 2024 | — | MiNK Therapeutics | Completed | No outcome recorded |
| Phase 1 | NCT05043714 Background | Dec 2021 → Nov 2023 | epithelial neoplasm, metastatic malignant neoplasm | Akamis Bio | Completed | No outcome recorded |
| Phase 1 | NCT05122546 Background | Nov 2021 → Jan 2027 expected | clear cell renal carcinoma, papillary renal cell carcinoma, sarcomatoid renal cell carcinoma | City of Hope Medical Center | Active not recruiting | No outcome recorded |
| Phase 1 | NCT04697576 Background | Oct 2021 → Sep 2027 expected | cutaneous melanoma, metastatic melanoma | Carlo Contreras | Recruiting | No outcome recorded |
| Phase 1 | NCT04900818 Background | Jun 2021 → Dec 2026 expected | biliary tract cancer, esophageal adenocarcinoma, gastric cancer, gastroesophageal cancer +2 | I-Mab Biopharma US Limited | Recruiting | No outcome recorded |
| Phase 1 | NCT04477512 Background | Feb → Sep 2021 | metastatic prostate carcinoma | Washington University School of Medicine | Completed | No outcome recorded |
| Phase 1 | NCT03929029 Background | Nov 2020 → Dec 2022 overdue | cutaneous melanoma | Dana-Farber Cancer Institute | Active not recruiting | No outcome recorded |
| Phase 1 | NCT04659369 Comparator | Sep 2020 → Oct 2023 | head and neck squamous cell carcinoma | Taizhou Mabtech Pharmaceutical Co.,Ltd | Terminated | No outcome recorded |
| Phase 1 | NCT04627246 Background | Sep 2020 → Sep 2028 expected | pancreatic adenocarcinoma | Centre Hospitalier Universitaire Vaudois | Active not recruiting | No outcome recorded |
| Phase 1 | NCT04387084 Background | Aug 2020 → Aug 2026 overdue | skin cancer | University of Southern California | Active not recruiting | No outcome recorded |
| Phase 1 | NCT04299880 Background | Feb 2020 → May 2021 | — | Sumitomo Pharma America, Inc. | Completed | No outcome recorded |
| Phase 1 | NCT03816358 Background | Dec 2019 → Jan 2027 expected | pancreatic adenocarcinoma | National Cancer Institute (NCI) | Active not recruiting | No outcome recorded |
| Phase 1 | NCT03892044 Background | Nov 2019 → Feb 2024 | Richter transformation, chronic lymphocytic leukemia/small lymphocytic lymphoma, diffuse large B-cell lymphoma | David Bond, MD | Completed | No outcome recorded |
| Phase 1 | NCT04050085 Background | Aug 2019 → Dec 2021 | pancreatic adenocarcinoma | University of California, Davis | Completed | No outcome recorded |
| Phase 1 | NCT03727061 Background | Jul 2019 → Oct 2024 | head and neck carcinoma | Roswell Park Cancer Institute | Terminated | No outcome recorded |
| Phase 1 | NCT03872947 Background | Apr 2019 → Jun 2026 overdue | cholangiocarcinoma, colorectal cancer, fallopian tube cancer, gastric cancer +5 | Toray Industries, Inc | Active not recruiting | No outcome recorded |
| Phase 1 | NCT03903458 Background | Mar 2019 → Dec 2021 | melanoma | Markus Joerger | Unknown | No outcome recorded |
| Phase 1 | NCT03655002 Background | Feb 2019 → Mar 2027 expected | hepatocellular carcinoma | City of Hope Medical Center | Active not recruiting | No outcome recorded |
| Phase 1 | NCT03817125 Background | Jan 2019 → Mar 2022 | metastatic melanoma | Parker Institute for Cancer Immunotherapy | Completed | No outcome recorded |
| Phase 1 | NCT03589339 Background | Jan 2019 → Apr 2027 expected | head and neck squamous cell carcinoma, high grade malignant neoplasm, metastatic melanoma, non-small cell lung carcinoma +5 | Nanobiotix | Active not recruiting | No outcome recorded |
| Phase 1 | NCT03406871 Comparator | Jan 2018 → Dec 2020 | — | Kohei Shitara | Completed | No outcome recorded |
| Phase 1 | NCT03181308 Background | Nov 2017 → Jul 2019 | non-small cell lung carcinoma | Tracon Pharmaceuticals Inc. | Completed | No outcome recorded |
| Phase 1 | NCT03203876 Background | Jul 2017 → Aug 2020 | cancer of unknown primary site | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1 | NCT02991196 Background | Dec 2016 → Sep 2017 | colorectal neoplasm | Daiichi Sankyo | Terminated | No outcome recorded |
| Phase 1 | NCT02437279 Comparator | Nov 2016 → Jun 2018 | cutaneous melanoma | The Netherlands Cancer Institute | Unknown | No outcome recorded |
| Phase 1 | NCT02935790 Background | Sep 2016 → Apr 2017 | melanoma | Celgene Corporation | Completed | No outcome recorded |
| Phase 1 | NCT02862535 Background | Sep 2016 → Oct 2019 | gastric adenocarcinoma | Gilead Sciences | Terminated | No outcome recorded |
| Phase 1 | NCT02890368 Background | Sep 2016 → Mar 2020 | breast carcinoma, cutaneous neuroendocrine carcinoma, melanoma, mycosis fungoides +2 | Pfizer | Terminated | No outcome recorded |
| Phase 1 | NCT02812667 Background | Aug 2016 → Nov 2024 | non-small cell lung carcinoma | Lyudmila Bazhenova, M.D. | Completed | No outcome recorded |
| Phase 1 | NCT02817633 Background | Jul 2016 → Mar 2027 expected | neoplasm | Tesaro, Inc. | Active not recruiting | No outcome recorded |
| Phase 1 | NCT02723006 Background | Jun 2016 → May 2018 | melanoma | Millennium Pharmaceuticals, Inc. | Terminated | No outcome recorded |
| Phase 1 | NCT02828098 Background | Jun 2016 → Jul 2020 | cancer | Highlight Therapeutics | Completed | No outcome recorded |
| Phase 1 | NCT02663518 Background | Jan 2016 → Nov 2022 | cancer, hematopoietic and lymphoid system neoplasm | Pfizer | Terminated | No outcome recorded |
| Phase 1 | NCT02534506 Background | Nov 2015 → Nov 2016 | cancer | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1 | NCT02419495 Background | Jun 2015 → Sep 2024 | cutaneous melanoma, fallopian tube carcinoma, metastatic malignant neoplasm, metastatic melanoma +5 | M.D. Anderson Cancer Center | Terminated | No outcome recorded |
| Phase 1 | NCT02293980 Background | Nov 2014 → Jan 2017 overdue | clear cell renal carcinoma | Peloton Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Active not recruiting | No outcome recorded |
| Phase 1/236 trials | ||||||
| Phase 1/2 | NCT07355205 Background | Jul 2026 → Jul 2032 expected | non-small cell lung carcinoma | Washington University School of Medicine | Recruiting | No outcome recorded |
| Phase 1/2 | NCT07615881 Background | Jul 2026 → Jul 2028 expected | melanoma | Amsterdam UMC, location VUmc | Not yet recruiting | No outcome recorded |
| Phase 1/2 | NCT07563738 Background | Mar 2026 → Sep 2029 expected | malignant pancreatic neoplasm, mesothelioma, non-small cell lung carcinoma | Orion Corporation, Orion Pharma | Recruiting | No outcome recorded |
| Phase 1/2 | NCT06963905 Comparator | Dec 2025 → Dec 2030 expected | triple-negative breast carcinoma | Yale University | Recruiting | No outcome recorded |
| Phase 1/2 | NCT05921760 Background | Oct 2023 → Nov 2024 | cancer | Servier Bio-Innovation LLC | Terminated | No outcome recorded |
| Phase 1/2 | NCT04954599 Background | May 2023 → Feb 2027 expected | cancer of unknown primary site | Maastricht University Medical Center | Recruiting | No outcome recorded |
| Phase 1/2 | NCT05838729 Background | Apr 2023 → Sep 2026 expected | head and neck cancer | Coordination Pharmaceuticals, Inc. | Recruiting | No outcome recorded |
| Phase 1/2 | NCT05423262 Background | Jul 2022 → Dec 2027 expected | cancer, melanoma | Toray Industries, Inc | Recruiting | No outcome recorded |
| Phase 1/2 | NCT05337137 Background | May 2022 → Jul 2025 | hepatocellular carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1/2 | NCT05116202 Comparator | Feb 2022 → Sep 2023 | melanoma | Hoffmann-La Roche | Completed | No outcome recorded |
| Phase 1/2 | NCT05163041 Background | Nov 2021 → Aug 2026 overdue | neoplasm | BicycleTx Limited | Active not recruiting | No outcome recorded |
| Phase 1/2 | NCT04060407 Background | Jun 2021 → Dec 2022 | metastatic melanoma | Merck & Co., Inc. | Withdrawn | No outcome recorded |
| Phase 1/2 | NCT04665206 Background | Mar 2021 → Nov 2029 expected | mesothelioma, non-small cell lung carcinoma | Vivace Therapeutics, Inc | Recruiting | No outcome recorded |
| Phase 1/2 | NCT04570839 Background | Aug 2020 → May 2024 | endometrium neoplasm, head and neck cancer, ovarian cancer | Compugen Ltd | Completed | No outcome recorded |
| Phase 1/2 | NCT04495296 Background | Aug 2020 → Jun 2026 overdue | cancer of unknown primary site | Suzhou Transcenta Therapeutics Co., Ltd. | Recruiting | No outcome recorded |
| Phase 1/2 | NCT04208958 Background | Jan 2020 → Aug 2021 | colorectal cancer, gastric cancer, gastroesophageal junction adenocarcinoma, melanoma +1 | Vedanta Biosciences, Inc. | Completed | No outcome recorded |
| Phase 1/2 | NCT03791398 Background | Nov 2019 → Jun 2021 | colorectal cancer | Brown University | Terminated | No outcome recorded |
| Phase 1/2 | NCT04180371 Background | Nov 2019 → Jul 2026 overdue | gastroesophageal cancer, head and neck cancer, non-small cell lung carcinoma, ovarian cancer +2 | BicycleTx Limited | Active not recruiting | No outcome recorded |
| Phase 1/2 | NCT03893695 Background | May 2019 → May 2022 | drug dependence, hepatocellular carcinoma | Suzhou Kintor Pharmaceutical Inc | Completed | No outcome recorded |
| Phase 1/2 | NCT03792750 Background | Dec 2018 → Dec 2020 | cancer of unknown primary site | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1/2 | NCT02842125 Background | Nov 2018 → May 2020 | head and neck squamous cell carcinoma, metastatic malignant neoplasm | MultiVir, Inc. | Terminated | No outcome recorded |
| Phase 1/2 | NCT03684811 Background | Nov 2018 → May 2021 | chondrosarcoma, intrahepatic cholangiocarcinoma, malignant glioma | Forma Therapeutics, Inc. | Completed | No outcome recorded |
| Phase 1/2 | NCT03354962 Background | Oct 2018 → Feb 2020 | melanoma | Institut Claudius Regaud | Terminated | No outcome recorded |
| Phase 1/2 | NCT03681561 Background | Sep 2018 → Sep 2026 expected | classic Hodgkin lymphoma | Veronika Bachanova | Recruiting | No outcome recorded |
| Phase 1/2 | NCT03633110 Background | Aug 2018 → Dec 2021 | cutaneous melanoma, head and neck squamous cell carcinoma, non-small cell lung carcinoma, renal cell carcinoma +1 | Genocea Biosciences, Inc. | Completed | No outcome recorded |
| Phase 1/2 | NCT03400332 Background | Feb 2018 → Apr 2024 | cancer, melanoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1/2 | NCT03707808 Background | Jan 2018 → Dec 2025 overdue | malignant soft tissue neoplasm | University Hospital Brussels | Recruiting | No outcome recorded |
| Phase 1/2 | NCT03167177 Background | Dec 2017 → Jan 2019 | melanoma | ImmunityBio, Inc. | Withdrawn | No outcome recorded |
| Phase 1/2 | NCT03009058 Background | May → Aug 2017 | metastatic malignant neoplasm | Immodulon Therapeutics Ltd | Terminated | No outcome recorded |
| Phase 1/2 | NCT02923531 Background | Dec 2016 → Aug 2018 | clear cell renal carcinoma | X4 Pharmaceuticals | Terminated | No outcome recorded |
| Phase 1/2 | NCT02771626 Background | Aug 2016 → Apr 2020 | clear cell renal carcinoma, melanoma, non-small cell lung carcinoma | Calithera Biosciences, Inc | Terminated | No outcome recorded |
| Phase 1/2 | NCT02718066 Background | Aug 2016 → Sep 2023 | melanoma, non-small cell lung carcinoma, renal cell carcinoma | HUYABIO International, LLC. | Completed | No outcome recorded |
| Phase 1/2 | NCT02712905 Background | May 2016 → Apr 2022 | hematopoietic and lymphoid system neoplasm | Incyte Corporation | Terminated | No outcome recorded |
| Phase 1/2 | NCT02658890 Background | Apr 2016 → Oct 2021 | melanoma, non-small cell lung carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1/2 | NCT02472977 Comparator | Jul 2015 → Jan 2017 | cancer | Bristol-Myers Squibb | Terminated | No outcome recorded |
| Phase 1/2 | NCT02118337 Comparator | May 2014 → Mar 2020 | clear cell renal carcinoma, high grade malignant neoplasm | MedImmune LLC | Completed | No outcome recorded |
| Phase 275 trials | ||||||
| Phase 2 | NCT07369791 Comparator | Dec 2026 → Dec 2035 | biliary tract cancer | National Health Research Institutes, Taiwan | Withdrawn | No outcome recorded |
| Phase 2 | NCT07188896 Comparator | Apr 2026 → Nov 2029 expected | clear cell renal carcinoma | Brian Rini | Recruiting | No outcome recorded |
| Phase 2 | NCT07510334 Background | Apr 2026 → Aug 2033 expected | clear cell renal carcinoma | Mayo Clinic | Recruiting | No outcome recorded |
| Phase 2 | NCT07213557 Background | Mar 2026 → Sep 2027 expected | gastroesophageal cancer | National Cancer Institute, Naples | Recruiting | No outcome recorded |
| Phase 2 | NCT07432295 Background | Feb 2026 → Mar 2030 expected | esophageal adenocarcinoma, gastric cancer, gastroesophageal cancer, metastatic malignant neoplasm | I-Mab Biopharma US Limited | Recruiting | No outcome recorded |
| Phase 2 | NCT07398937 Comparator | Feb 2026 → Dec 2027 expected | — | Fudan University | Recruiting | No outcome recorded |
| Phase 2 | NCT07226856 Background | Dec 2025 → Dec 2028 expected | pancreatic adenocarcinoma | Mayo Clinic | Recruiting | No outcome recorded |
| Phase 2 | NCT06948448 Background | Nov 2025 → Feb 2028 expected | colorectal cancer | Ono Pharmaceutical Co., Ltd. | Recruiting | No outcome recorded |
| Phase 2 | NCT07223424 Comparator | Nov 2025 → Nov 2030 expected | cervical cancer, colorectal cancer, esophageal adenocarcinoma, gastroesophageal adenocarcinoma +7 | Diwakar Davar | Recruiting | No outcome recorded |
| Phase 2 | NCT05835804 Background | Nov 2025 → Apr 2026 overdue | head and neck squamous cell carcinoma | Centre Hospitalier Universitaire, Amiens | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT07152678 Background | Sep 2025 → Sep 2027 expected | esophageal squamous cell carcinoma | National Taiwan University Hospital | Recruiting | No outcome recorded |
| Phase 2 | NCT06983210 Background | May 2025 → Mar 2027 expected | carcinoma of urethra, renal pelvis/ureter urothelial carcinoma, urinary bladder carcinoma | Nagoya University | Recruiting | No outcome recorded |
| Phase 2 | NCT06731270 Background | Apr 2025 → Jan 2027 expected | non-small cell lung carcinoma | Emory University | Recruiting | No outcome recorded |
| Phase 2 | NCT06888037 Background | Mar 2025 → Mar 2028 expected | gastric adenocarcinoma, gastroesophageal junction adenocarcinoma | Ruijin Hospital | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06245356 Background | Mar 2025 → Oct 2026 expected | colorectal cancer, dihydropyrimidine dehydrogenase deficiency, gastroesophageal adenocarcinoma | UNICANCER | Recruiting | No outcome recorded |
| Phase 2 | NCT06534190 Background | Mar 2025 → Nov 2028 expected | — | University Medical Center Groningen | Recruiting | No outcome recorded |
| Phase 2 | NCT06745076 Background | Mar 2025 → Jan 2032 expected | classic Hodgkin lymphoma | University of Washington | Recruiting | No outcome recorded |
| Phase 2 | NCT06554613 Background | Jul 2024 → Dec 2026 expected | non-small cell lung carcinoma | Second Affiliated Hospital of Nanchang University | Recruiting | No outcome recorded |
| Phase 2 | NCT06728657 Background | Jul 2024 → Dec 2025 | gastric adenocarcinoma, gastroesophageal junction adenocarcinoma | Fudan University | Suspended | No outcome recorded |
| Phase 2 | NCT06253611 Background | Apr 2024 → Sep 2027 expected | gastric cancer | GERCOR - Multidisciplinary Oncology Cooperative Group | Recruiting | No outcome recorded |
| Phase 2 | NCT06250335 Background | Mar 2024 → Jan 2027 expected | refractory malignant neoplasm | M.D. Anderson Cancer Center | Active not recruiting | No outcome recorded |
| Phase 2 | NCT06237920 Background | Feb 2024 → Dec 2026 expected | poisoning, urinary bladder carcinoma, urothelial carcinoma | The Netherlands Cancer Institute | Active not recruiting | No outcome recorded |
| Phase 2 | NCT06256328 Background | Jan 2024 → Oct 2025 overdue | gastric cancer | Ono Pharmaceutical Co., Ltd. | Active not recruiting | No outcome recorded |
| Phase 2 | NCT06094296 Background | Nov 2023 → Aug 2024 | non-small cell lung carcinoma | Bristol-Myers Squibb | Terminated | No outcome recorded |
| Phase 2 | NCT06084897 Background | Oct 2023 → Apr 2026 overdue | esophageal cancer | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Recruiting | No outcome recorded |
| Phase 2 | NCT05928806 Comparator | Sep 2023 → Nov 2026 | renal cell carcinoma | Michael B. Atkins, MD | Suspended | No outcome recorded |
| Phase 2 | NCT06059547 Background | Sep 2023 → Oct 2025 overdue | urinary bladder cancer | CatalYm GmbH | Active not recruiting | No outcome recorded |
| Phase 2 | NCT05846659 Background | Jul 2023 → Nov 2024 | — | ImmuneSensor Therapeutics Inc. | Terminated | No outcome recorded |
| Phase 2 | NCT05846646 Background | Jun 2023 → Sep 2024 | — | ImmuneSensor Therapeutics Inc. | Terminated | No outcome recorded |
| Phase 2 | NCT05926960 Comparator | Jun 2023 → Feb 2026 | melanoma | Pfizer | Terminated | No outcome recorded |
| Phase 2 | NCT05817903 Background | Apr 2023 → Apr 2026 overdue | renal cell carcinoma | Consorzio Oncotech | Recruiting | No outcome recorded |
| Phase 2 | NCT05317000 Comparator | Mar 2023 → Jun 2028 expected | head and neck squamous cell carcinoma | Barbara Burtness | Recruiting | No outcome recorded |
| Phase 2 | NCT05633667 Comparator | Mar 2023 → Sep 2029 expected | non-small cell lung carcinoma | Gilead Sciences | Active not recruiting | No outcome recorded |
| Phase 2 | NCT05428007 Background | Feb 2023 → Aug 2026 overdue | melanoma | NYU Langone Health | Recruiting | No outcome recorded |
| Phase 2 | NCT05500092 Background | Jan 2023 → Jul 2025 overdue | non-small cell lung carcinoma | Montefiore Medical Center | Active not recruiting | No outcome recorded |
| Phase 2 | NCT04991025 Background | Oct 2022 → Oct 2026 expected | lung carcinoma | Memorial Sloan Kettering Cancer Center | Recruiting | No outcome recorded |
| Phase 2 | NCT05005273 Background | Oct → Dec 2022 | non-small cell lung carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 2 | NCT04782791 Comparator | May 2022 → Dec 2023 | chemotherapy-induced toxicity, gastric cancer | Chinese PLA General Hospital | Unknown | No outcome recorded |
| Phase 2 | NCT05144529 Background | Mar 2022 → Sep 2024 | lung cancer | Eziafa Oduah, MD, PhD, MPH | Terminated | No outcome recorded |
| Phase 2 | NCT05263050 Background | Jan 2022 → Dec 2026 expected | carcinoid tumor, clear cell renal carcinoma | Fox Chase Cancer Center | Recruiting | No outcome recorded |
| Phase 2 | NCT04988841 Background | Jan 2022 → Aug 2024 | melanoma | Assistance Publique - Hôpitaux de Paris | Completed | No outcome recorded |
| Phase 2 | NCT04951583 Background | Nov 2021 → Sep 2024 overdue | melanoma, non-small cell lung carcinoma | University of Montreal Hospital Centre (CHUM) | Active not recruiting | No outcome recorded |
| Phase 2 | NCT04899921 Background | Jun 2021 → May 2023 | metastatic melanoma | Dana-Farber Cancer Institute | Terminated | No outcome recorded |
| Phase 2 | NCT04785820 Comparator | Jun 2021 → Jan 2025 | esophageal squamous cell carcinoma | Hoffmann-La Roche | Completed | No outcome recorded |
| Phase 2 | NCT04702880 Background | Mar 2021 → May 2025 | small cell lung carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 2 | NCT04623775 Background | Feb 2021 → Jan 2024 | non-small cell lung carcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 2 | NCT06884683 Background | Sep 2020 → Sep 2023 | renal cell carcinoma | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Terminated | No outcome recorded |
| Phase 2 | NCT04203901 Background | Jul 2020 → Sep 2023 | renal cell carcinoma | CoImmune | Terminated | No outcome recorded |
| Phase 2 | NCT04382664 Background | May 2020 → Jan 2024 | melanoma | Ultimovacs ASA | Completed | No outcome recorded |
| Phase 2 | NCT04090710 Comparator | Jan 2020 → Jun 2026 overdue | renal cell carcinoma | Ontario Clinical Oncology Group (OCOG) | Active not recruiting | No outcome recorded |
| Phase 2 | NCT05081674 Comparator | Jan 2020 → Jun 2023 | lung neoplasm | Hospital Israelita Albert Einstein | Completed | No outcome recorded |
| Phase 2 | NCT04079166 Background | Aug 2019 → Jan 2027 expected | cutaneous melanoma | Scancell Ltd | Active not recruiting | No outcome recorded |
| Phase 2 | NCT03340129 Comparator | Aug 2019 → Aug 2026 overdue | melanoma | Melanoma Institute Australia | Recruiting | No outcome recorded |
| Phase 2 | NCT03719131 Background | Jun 2019 → Sep 2022 overdue | cutaneous melanoma | Emory University | Active not recruiting | No outcome recorded |
| Phase 2 | NCT03785925 Background | Apr 2019 → Feb 2022 | metastatic neoplasm, urinary bladder neoplasm | Nektar Therapeutics | Completed | No outcome recorded |
| Phase 2 | NCT03808168 Comparator | Jan → Jun 2019 | cervix disorder | University of Texas Southwestern Medical Center | Withdrawn | No outcome recorded |
| Phase 2 | NCT03662659 Background | Oct 2018 → Aug 2020 | gastric cancer, gastroesophageal junction adenocarcinoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 2 | NCT03693014 Background | Oct 2018 → Oct 2026 expected | head and neck cancer, kidney cancer, lung cancer, melanoma +2 | Memorial Sloan Kettering Cancer Center | Active not recruiting | No outcome recorded |
| Phase 2 | NCT03544723 Background | Oct 2018 → Jun 2022 | cancer, lymphoma | MultiVir, Inc. | Unknown | No outcome recorded |
| Phase 2 | NCT03547999 Background | Jun 2018 → Mar 2024 | colorectal cancer | Patrick Boland | Terminated | No outcome recorded |
| Phase 2 | NCT03514901 Comparator | Jun 2018 → Apr 2023 | metastatic melanoma | Italian Melanoma Intergroup | Unknown | No outcome recorded |
| Phase 2 | NCT03511391 Background | Mar 2018 → Feb 2022 | head and neck cancer, melanoma, non-small cell lung carcinoma, renal cell carcinoma +1 | University Hospital, Ghent | Completed | No outcome recorded |
| Phase 2 | NCT03302247 Background | Jan 2018 → Mar 2019 | non-small cell lung carcinoma | Fox Chase Cancer Center | Terminated | No outcome recorded |
| Phase 2 | NCT03313804 Background | Oct 2017 → Feb 2024 | head and neck squamous cell carcinoma, non-small cell lung carcinoma | John L. Villano, MD, PhD | Completed | No outcome recorded |
| Phase 2 | NCT03121534 Background | Jun 2017 → Feb 2022 | Richter transformation, hematopoietic and lymphoid system neoplasm | M.D. Anderson Cancer Center | Terminated | No outcome recorded |
| Phase 2 | NCT03071406 Comparator | Mar 2017 → Apr 2022 overdue | cutaneous neuroendocrine carcinoma | H. Lee Moffitt Cancer Center and Research Institute | Active not recruiting | No outcome recorded |
| Phase 2 | NCT02831933 Background | Feb 2017 → Nov 2020 | non-small cell squamous lung carcinoma, uveal melanoma | Eric Bernicker, MD | Terminated | No outcome recorded |
| Phase 2 | NCT02996110 Background | Feb 2017 → Nov 2021 | — | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 2 | NCT02967133 Comparator | Dec 2016 → Jan 2018 | non-small cell lung carcinoma | Alliance Foundation Trials, LLC. | Terminated | No outcome recorded |
| Phase 2 | NCT03115801 Comparator | Nov 2016 → Oct 2020 | renal cell carcinoma, urothelial carcinoma | Weill Medical College of Cornell University | Terminated | No outcome recorded |
| Phase 2 | NCT02750514 Background | May 2016 → Jan 2020 | cancer of unknown primary site | Bristol-Myers Squibb | Terminated | No outcome recorded |
| Phase 2 | NCT02852083 Comparator | Jan 2016 → Jul 2019 | non-small cell lung carcinoma, squamous cell lung carcinoma | University Hospital Regensburg | Unknown | No outcome recorded |
| Phase 2 | NCT02523313 Comparator | Sep 2015 → Jun 2021 | melanoma | Prof. Dr. med. Dirk Schadendorf | Completed | No outcome recorded |
| Phase 2 | NCT02499367 Comparator | Aug 2015 → Dec 2023 | breast cancer | The Netherlands Cancer Institute | Unknown | No outcome recorded |
| Phase 2 | NCT02374242 Comparator | Nov 2014 → Sep 2017 overdue | melanoma, metastatic malignant neoplasm in the brain | Melanoma Institute Australia | Active not recruiting | No outcome recorded |
| Phase 2/38 trials | ||||||
| Phase 2/3 | NCT07392892 Comparator | May 2026 → Jul 2031 expected | esophageal adenocarcinoma, gastric cancer, gastroesophageal cancer | Pfizer | Recruiting | No outcome recorded |
| Phase 2/3 | NCT06841679 Background | Aug 2025 → Sep 2030 expected | gastroesophageal adenocarcinoma | Beijing Biostar Pharmaceuticals Co., Ltd. | Recruiting | No outcome recorded |
| Phase 2/3 | NCT06624644 Comparator | Aug 2025 → Feb 2029 expected | cutaneous melanoma | Linnaeus Therapeutics, Inc. | Recruiting | No outcome recorded |
| Phase 2/3 | NCT06581406 Background | Dec 2024 → Jan 2030 expected | uveal melanoma | Replimune, Inc. | Recruiting | No outcome recorded |
| Phase 2/3 | NCT05987332 Comparator | Oct 2023 → Jan 2027 expected | uveal melanoma | IDEAYA Biosciences | Active not recruiting | No outcome recorded |
| Phase 2/3 | NCT04929041 Background | Oct 2022 → Dec 2030 | adenosquamous lung carcinoma, lung adenocarcinoma | National Cancer Institute (NCI) | Suspended | No outcome recorded |
| Phase 2/3 | NCT04887870 Background | Jun 2021 → Apr 2025 | cancer of unknown primary site | Mirati Therapeutics Inc. | Completed | No outcome recorded |
| Phase 2/3 | NCT02339571 Background | Nov 2015 → Jun 2033 expected | cutaneous melanoma | National Cancer Institute (NCI) | Active not recruiting | No outcome recorded |
| Phase 339 trials | ||||||
| Phase 3 | NCT07541170 Comparator | Sep 2026 → Jan 2032 expected | non-small cell lung carcinoma | Hoffmann-La Roche | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07700979 Comparator | Aug 2026 → Aug 2029 expected | gastroesophageal adenocarcinoma | Akeso | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07672223 Comparator | Jun 2026 → Sep 2029 expected | non-small cell lung carcinoma | CSPC Megalith Biopharmaceutical Co.,Ltd. | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07383441 Background | Jun 2026 → Jan 2033 expected | clear cell renal carcinoma | SWOG Cancer Research Network | Recruiting | No outcome recorded |
| Phase 3 | NCT07620574 Background | May 2026 → May 2030 expected | colorectal cancer, differentiated thyroid carcinoma, hepatocellular carcinoma, pancreatic neuroendocrine tumor +2 | Exelixis | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07338981 Comparator | Apr 2026 → Dec 2030 expected | kidney cancer | Guliz Ozgun | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07405164 Background | Mar 2026 → Jan 2034 expected | cancer, von Hippel-Lindau disease | Merck Sharp & Dohme LLC | Recruiting | No outcome recorded |
| Phase 3 | NCT07195695 Comparator | Jan 2026 → Feb 2032 expected | non-small cell lung carcinoma | Boehringer Ingelheim | Recruiting | No outcome recorded |
| Phase 3 | NCT07221734 Comparator | Dec 2025 → Apr 2027 expected | melanoma | mAbxience Research S.L. | Recruiting | No outcome recorded |
| Phase 3 | NCT06908993 Comparator | Dec 2025 → Mar 2028 expected | non-small cell lung carcinoma | French Cooperative Thoracic Intergroup | Recruiting | No outcome recorded |
| Phase 3 | NCT06840782 Background | Sep 2025 → Feb 2030 expected | non-small cell lung carcinoma | Gustave Roussy, Cancer Campus, Grand Paris | Recruiting | No outcome recorded |
| Phase 3 | NCT07000149 Comparator | Jul 2025 → Feb 2030 expected | clear cell renal carcinoma | AstraZeneca | Active not recruiting | No outcome recorded |
| Phase 3 | NCT06794775 Comparator | Jul 2025 → Apr 2032 expected | melanoma | Hildur Helgadottir | Recruiting | No outcome recorded |
| Phase 3 | NCT06841185 Background | Apr 2025 → Jun 2027 expected | hepatocellular carcinoma | Shanghai Henlius Biotech | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT06743126 Comparator | Jan 2025 → Jan 2028 expected | cutaneous melanoma | Immatics US, Inc. | Recruiting | No outcome recorded |
| Phase 3 | NCT06587451 Comparator | Dec 2024 → Jan 2026 | melanoma | Sandoz | Terminated | No outcome recorded |
| Phase 3 | NCT06246916 Comparator | Sep 2024 → Mar 2027 expected | melanoma | Regeneron Pharmaceuticals | Recruiting | No outcome recorded |
| Phase 3 | NCT06519266 Comparator | Jun 2024 → Dec 2028 expected | uveal melanoma | Vastra Gotaland Region | Recruiting | No outcome recorded |
| Phase 3 | NCT06097728 Comparator | Nov 2023 → Nov 2028 expected | pleural mesothelioma | AstraZeneca | Active not recruiting | No outcome recorded |
| Phase 3 | NCT06054555 Comparator | Nov 2023 → Jan 2028 expected | melanoma | Amgen | Active not recruiting | No outcome recorded |
| Phase 3 | NCT06022861 Comparator | Oct 2023 → Jun 2025 overdue | esophageal squamous cell carcinoma | Shandong Boan Biotechnology Co., Ltd | Recruiting | No outcome recorded |
| Phase 3 | NCT05907122 Comparator | Jul 2023 → Mar 2025 | melanoma | Amgen | Completed | No outcome recorded |
| Phase 3 | NCT05677490 Background | Jan 2023 → Nov 2028 expected | esophageal adenocarcinoma, gastric adenocarcinoma, gastroesophageal junction adenocarcinoma | Alliance for Clinical Trials in Oncology | Recruiting | No outcome recorded |
| Phase 3 | NCT05568095 Comparator | Nov 2022 → Jun 2026 overdue | adenocarcinoma | Arcus Biosciences, Inc. | Active not recruiting | No outcome recorded |
| Phase 3 | NCT05317858 Background | Aug 2022 → Jun 2027 expected | brain neoplasm, non-small cell lung carcinoma | InSightec | Recruiting | No outcome recorded |
| Phase 3 | NCT05297565 Comparator | Aug 2022 → Feb 2024 | melanoma | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 3 | NCT05111626 Background | Mar 2022 → Oct 2025 | gastric cancer, gastroesophageal junction adenocarcinoma | Amgen | Terminated | No outcome recorded |
| Phase 3 | NCT05111197 Background | Jan 2022 → Jan 2025 | non-small cell lung carcinoma | Institut Cancerologie de l'Ouest | Unknown | No outcome recorded |
| Phase 3 | NCT04674683 Background | Aug 2021 → Jul 2026 overdue | metastatic malignant neoplasm in the brain, metastatic melanoma | HUYABIO International, LLC. | Active not recruiting | No outcome recorded |
| Phase 3 | NCT04810078 Comparator | May 2021 → Jul 2025 overdue | clear cell renal carcinoma | Bristol-Myers Squibb | Active not recruiting | No outcome recorded |
| Phase 3 | NCT04510597 Comparator | Mar 2021 → Jul 2033 expected | clear cell renal carcinoma | SWOG Cancer Research Network | Recruiting | No outcome recorded |
| Phase 3 | NCT04334759 Comparator | Feb 2021 → Jun 2025 | malignant pleural mesothelioma | PrECOG, LLC. | Completed | No outcome recorded |
| Phase 3 | NCT04157985 Comparator | Nov 2019 → Oct 2025 | anal carcinoma, cervical cancer, cholangiocarcinoma, cutaneous neuroendocrine carcinoma +7 | Dan Zandberg | Completed | No outcome recorded |
| Phase 3 | NCT03937219 Background | Jun 2019 → Jan 2022 overdue | renal cell carcinoma | Exelixis | Active not recruiting | No outcome recorded |
| Phase 3 | NCT03873402 Background | Jun 2019 → Mar 2027 expected | renal cell carcinoma | Bristol-Myers Squibb | Active not recruiting | No outcome recorded |
| Phase 3 | NCT03793166 Background | Jun 2019 → Jan 2028 expected | clear cell renal carcinoma, metastatic carcinoma in the bone, metastatic malignant neoplasm in the lymph nodes, rhabdoid tumor of the kidney +1 | National Cancer Institute (NCI) | Active not recruiting | No outcome recorded |
| Phase 3 | NCT03520686 Background | May 2018 → Oct 2025 | non-small cell lung carcinoma | ImmunityBio, Inc. | Terminated | No outcome recorded |
| Phase 3 | NCT02973789 Background | Dec 2016 → Sep 2024 | non-small cell lung carcinoma | NovoCure Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT02821013 Comparator | Oct 2016 → Dec 2027 expected | metastatic melanoma | Canadian Cancer Trials Group | Recruiting | No outcome recorded |
| Phase 47 trials | ||||||
| Phase 4 | NCT07504796 Background | Apr 2026 → May 2029 expected | metastatic melanoma | NYU Langone Health | Recruiting | No outcome recorded |
| Phase 4 | NCT07028125 Background | Oct 2025 → Oct 2028 expected | renal cell carcinoma | Centre Francois Baclesse | Recruiting | No outcome recorded |
| Phase 4 | NCT06903312 Comparator | Jun 2025 → Oct 2027 expected | renal cell carcinoma | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Recruiting | No outcome recorded |
| Phase 4 | NCT05583188 Background | Feb 2023 → Feb 2024 | non-small cell lung carcinoma | Galvanize Therapeutics, Inc. | Terminated | No outcome recorded |
| Phase 4 | NCT04707547 Comparator | Oct 2019 → Jul 2020 | liver cancer | Taipei Medical University WanFang Hospital | Completed | No outcome recorded |
| Phase 4 | NCT03313544 Background | Apr 2018 → Oct 2024 | melanoma, non-small cell lung carcinoma | Assistance Publique Hopitaux De Marseille | Unknown | No outcome recorded |
| Phase 4 | NCT02626065 Background | Apr 2015 → Dec 2017 | metastatic melanoma | Hospices Civils de Lyon | Completed | No outcome recorded |
| Phase not applicable7 trials | ||||||
| — | NCT06519682 Comparator | Dec 2024 → Dec 2026 expected | DNA repair disease, high grade astrocytic tumor | Daniel Morgenstern | Recruiting | No outcome recorded |
| — | NCT06702566 Background | Jul 2024 → Jul 2026 overdue | acute leukemia, cancer | Tianjin Medical University Cancer Institute and Hospital | Recruiting | No outcome recorded |
| — | NCT07436390 Background | Mar 2024 | metastatic melanoma, skin cancer | Institute of Oncology Ljubljana | Completed | No outcome recorded |
| — | NCT05834413 Background | May 2023 → Jun 2027 expected | lung cancer | Shanghai University of Traditional Chinese Medicine | Recruiting | No outcome recorded |
| — | NCT05233358 Background | Feb 2022 → Feb 2023 | hepatocellular carcinoma | The Central Hospital of Lishui City | Unknown | No outcome recorded |
| — | NCT05821751 Background | Dec 2021 → Dec 2024 | head and neck squamous cell carcinoma | Fondazione del Piemonte per l'Oncologia | Unknown | No outcome recorded |
| — | NCT07537985 Background | Jan 2020 → Aug 2025 | hepatocellular carcinoma | Sun Yat-sen University | Completed | No outcome recorded |
| Phase not stated3 trials | ||||||
| — | NCT06590480 Background | — | melanoma | Replimune, Inc. | No longer available | No outcome recorded |
| — | NCT03126643 Background | — | childhood malignant neoplasm | Bristol-Myers Squibb | Approved for marketing | No outcome recorded |
| — | NCT05170685 Background | — | — | Bristol-Myers Squibb | No longer available | No outcome recorded |
Press releases naming this drug 35 releases
| Date | Issuer | Release |
|---|---|---|
| 2026-06-01 | Bristol-Myers Squibb | Bristol Myers Squibb Announces Opdivo® (nivolumab) in Combination with AVD Receives Expanded EU Label with Approval in Frontline Advanced Classical Hodgkin Lymphoma bms.com ↗ |
| 2023-08-22 | Ipsen | European Commission approves Cabometyx® in combination with Opdivo® as a first-line treatment for patients living with advanced renal cell carcinoma ipsen.com ↗ |
| 2023-08-17 | Ipsen | Cabometyx® in combination with Opdivo® demonstrated continued survival and quality of life benefits with over two years of follow-up in the Phase III CheckMate -9ER trial ipsen.com ↗ |
| 2023-02-13 | Ipsen | Cabometyx® in combination with nivolumab shows durable survival benefits at over three-years’ follow-up in first-line advanced renal cell carcinoma ipsen.com ↗ |
| 2022-04-14 | Bristol-Myers Squibb | Nektar and Bristol Myers Squibb Announce Update on Clinical Development Program for Bempegaldesleukin (BEMPEG) in Combination with Opdivo (nivolumab) bms.com ↗ |
| 2022-04-11 | Bristol-Myers Squibb | Neoadjuvant Opdivo (nivolumab) with Chemotherapy Significantly Improves Event-Free Survival in Patients with Resectable Non-Small Cell Lung Cancer in Phase 3 CheckMate -816 Trial bms.com ↗ |
| 2022-04-05 | Bristol-Myers Squibb | Bristol Myers Squibb Receives European Commission Approval for Opdivo (nivolumab) with Chemotherapy as First-Line Treatment for Patients with... bms.com ↗ |
| 2022-04-05 | Bristol-Myers Squibb | Bristol Myers Squibb Receives European Commission Approval for Opdivo (nivolumab) as Adjuvant Treatment for Patients with Radically Resected, High-Risk Muscle-Invasive Urothelial Carcinoma with Tumor Cell PD-L1 Expression ≥1% bms.com ↗ |
| 2022-04-05 | Bristol-Myers Squibb | Bristol Myers Squibb Receives European Commission Approval for Opdivo (nivolumab) Plus Yervoy (ipilimumab) as First-Line Treatment for Patients with... bms.com ↗ |
| 2022-03-29 | Bristol-Myers Squibb | European Medicines Agency Validates Bristol Myers Squibb’s Application for Opdivo (nivolumab) with Chemotherapy as Neoadjuvant Treatment for Resectable Non-Small Cell Lung Cancer bms.com ↗ |
| 2022-03-18 | Bristol-Myers Squibb | U.S. Food and Drug Administration Approves First LAG-3-Blocking Antibody Combination, Opdualag™ (nivolumab and relatlimab-rmbw), as Treatment for Patients with Unresectable or Metastatic Melanoma bms.com ↗ |
| 2022-03-14 | Bristol-Myers Squibb | Bristol Myers Squibb and Nektar Announce Update on Phase 3 PIVOT IO-001 Trial Evaluating Bempegaldesleukin (BEMPEG) in Combination with Opdivo (nivolumab) in Previously Untreated Unresectable or Metastatic Melanoma bms.com ↗ |
| 2022-03-04 | Bristol-Myers Squibb | U.S. Food and Drug Administration Approves Opdivo® (nivolumab) with Chemotherapy as Neoadjuvant Treatment for Certain Adult Patients with Resectable Non-Small Cell Lung Cancer bms.com ↗ |
| 2022-02-15 | Ipsen | Cabometyx® in combination with Opdivo® demonstrated continued survival and quality of life benefits with over two years of follow-up in the Phase III CheckMate -9ER trial ipsen.com ↗ |
| 2021-03-31 | Ipsen | European Commission approves Cabometyx® in combination with Opdivo® as a first-line treatment for patients living with advanced renal cell carcinoma ipsen.com ↗ |
| 2021-02-26 | Ipsen | Ipsen receives positive CHMP opinion recommending Cabometyx® in combination with Opdivo® as first-line treatment for patients living with advanced renal cell carcinoma ipsen.com ↗ |
| 2021-02-08 | Ipsen | New data from pivotal Phase III CheckMate -9ER trial of Cabometyx® in combination with Opdivo® showed significantly improved QoL benefits and sustained superior efficacy versus sunitinib in patients living with aRCC ipsen.com ↗ |
| 2020-09-19 | Ipsen | ESMO 2020: Cabometyx® (cabozantinib) in combination with Opdivo® (nivolumab) demonstrates significant survival benefits in patients with advanced renal cell carcinoma in pivotal Phase III CheckMate -9ER trial ipsen.com ↗ |
| 2020-04-20 | Ipsen | Ipsen announces positive topline results from pivotal Phase III CheckMate -9ER trial evaluating CABOMETYX® (cabozantinib) in combination with Opdivo® (nivolumab) in previously untreated advanced renal cell carcinoma ipsen.com ↗ |
| 2019-02-14 | Bristol-Myers Squibb | Opdivo (nivolumab) Plus Yervoy (ipilimumab) Shows Response in Pre-Treated Patients with Metastatic Castration-Resistant Prostate Cancer bms.com ↗ |
| 2019-02-11 | Bristol-Myers Squibb | Opdivo (nivolumab) Plus Low-Dose Yervoy (ipilimumab) Demonstrates Continued Survival Benefit at 30-Month Follow-up in Patients with Previously Untreated Advanced or Metastatic Renal Cell Carcinoma bms.com ↗ |
| 2019-01-14 | Bristol-Myers Squibb | European Commission Approves Opdivo (nivolumab) Plus Low-Dose Yervoy (ipilimumab) for First-Line Treatment of Patients with Intermediate- and Poor-Risk Advanced Renal Cell Carcinoma bms.com ↗ |
| 2017-08-29 | Daiichi Sankyo | Bristol-Myers Squibb and Daiichi Sankyo Announce Research Collaboration to Evaluate Opdivo® (nivolumab) and DS-8201 in HER2-Expressing Breast and Bladder Cancers daiichisankyo.com ↗ |
| 2017-06-05 | Incyte Corporation | Clinical Trial Data for Combination of Epacadostat and Opdivo® (nivolumab) Demonstrate Durable Clinical Responses in Patients with Melanoma and Head and Neck Cancer incyte.com ↗ |
| 2017-05-17 | Incyte Corporation | First Data from Combination of Epacadostat with Opdivo® (nivolumab) Will Be Highlighted at ASCO 2017 incyte.com ↗ |
| 2017-04-02 | Incyte Corporation | Bristol-Myers Squibb and Incyte to Advance the Combination of Opdivo (nivolumab) and Epacadostat into First-line Registrational Trials incyte.com ↗ |
| 2016-07-25 | AbbVie | AbbVie and Bristol-Myers Squibb Announce Oncology Clinical Collaboration to Evaluate the Combination of Rova-T plus Opdivo and Opdivo + Yervoy Regimen abbvie.com ↗ |
| 2015-12-23 | Bristol-Myers Squibb | Seattle Genetics and Bristol-Myers Squibb Announce Initiation of Phase 1/2 Clinical Trial of ADCETRIS® (Brentuximab Vedotin) in Combination with Opdivo® (Nivolumab) in Relapsed or Refractory Non-Hodgkin Lymphoma bms.com ↗ |
| 2015-11-27 | Bristol-Myers Squibb | Bristol-Myers Squibb Announces Regulatory Update for Opdivo (nivolumab) in Advanced Melanoma bms.com ↗ |
| 2015-11-24 | Bristol-Myers Squibb | European Commission Approves Reconciliation of Indications for nivolumab Under the Opdivo® European Marketing Authorization Application bms.com ↗ |
| 2015-11-24 | Bristol-Myers Squibb | Bristol-Myers Squibb Announces U.S. Food and Drug Administration Approval for Opdivo (nivolumab) as a Single Agent for the Treatment of Patients with Previously Untreated BRAF Wild-Type Advanced Melanoma bms.com ↗ |
| 2015-11-23 | Bristol-Myers Squibb | Bristol-Myers Squibb Receives FDA Approval for Opdivo (nivolumab), the Only Treatment to Deliver Significant Overall Survival in Advanced Renal Cell Carcinoma vs. a Standard of Care, in Patients Who Have Received Prior Anti-Angiogenic Therapy1 bms.com ↗ |
| 2015-11-18 | Bristol-Myers Squibb | New Long-Term Data on Opdivo and the Opdivo + Yervoy Regimen Shows Survival Benefit Across Lines of Therapy in Advanced Melanoma bms.com ↗ |
| 2015-11-16 | Bristol-Myers Squibb | U.S. Food and Drug Administration Accepts for Priority Review the Supplemental Biologics License Application for Opdivo (nivolumab) in Patients with Advanced Renal Cell Carcinoma bms.com ↗ |
| 2012-06-02 | Bristol-Myers Squibb | Investigational Anti-PD-1 Immunotherapy BMS-936558 Showed Clinical Activity in Phase 1 Trial of Patients with Previously-Treated Non-Small-Cell Lung Cancer, Metastatic Melanoma and Renal Cell Cancer bms.com ↗ |
Evidence & citations 43 cited values
Every value below carries the sentence it was read from. 1,762 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | nivolumab | “Nivolumab administered IV over 30-60 minutes at 1 mg/kg (combined with ipilimumab administered IV over 85-100 minutes at 3 mg/kg) every 3 weeks for a total of 4 doses of the...” NCT05169957 ↗1690“EO2401 is an innovative cancer peptide therapeutic vaccine based on the homologies between Tumor Associated Antigens and microbiome-derived peptides that will be administered...” NCT04116658 ↗ “Standard of Care Drugs (at investigator's discretion) may include: pembrolizumab, nivolumab, cemiplimab, durvalumab, dostarlimab, avelumab, and atezolizumab, or other immune...” NCT07224971 ↗ “Medical therapy is the continuation of the immune-based combo for mRCC including one of the available options among axitinib + pembrolizumab or cabozantinib + nivolumab or...” NCT06903312 ↗ “This open-label, multicenter, dose-escalation and expansion trial is designed to evaluate the safety and preliminary efficacy of inhaled DV281 in combination with nivolumabfor...” NCT03326752 ↗ “Phase 2 Randomized Clinical Trial Comparing the Safety and Efficacy of PULSAR-Integrated Radiotherapy + Pembrolizumab or Nivolumab Administered With or Without STING-Agonist...” NCT05846659 ↗ “This editorial proposes that the TGF-β trap of AdAPT-001 reverses the immunosuppressive environment of tumor cells, and thus makes these tumors susceptible to CIs like the...” PMID 39461878 ↗ Oct 2024 “Nivolumab/Toripalimab 240mg solution intravenously once daily, Q2W. OR Nivolumab/Toripalimab 360mg solution intravenously once daily, Q3W; OR...” NCT04997837 ↗ “TTI-621 will be given in combination with one of the following programmed death-1 (PD-1) or programmed death-ligand-1 (PD-L1) inhibitors: nivolumab, pembrolizumab, durvalumab,...” NCT02890368 ↗ “Nivolumab 240 mg IV will be started 1 to 7 days before the first intratumoral infusion and every 15 days, until progression or 2 until years in case of partial response,...” NCT05835804 ↗ “Nivolumab is approved for use for the treatment of multiple cancer types, including subtypes of CRC (mismatch repair deficient or microsatellite instability-high metastatic...” NCT05350501 ↗ “Fixed Delay Arm Delayed PD-1 + Chemo PD-1 inhibitor (e.g., Sintilimab/Keytruda/Tislelizumab/Camrelizumab/Toripalimab/Nivolumab/Atezolizumab/Sugemalimab) Immune checkpoint...” NCT07190027 ↗ “Integrated Pharmacokinetics (PK)/Efficacy, Safety, and Immunogenicity Study to Demonstrate Similarity of JPB898, a Proposed Biosimilar to Nivolumab, to Opdivo® in Combination...” NCT06587451 ↗ “The commonly used anti-PD-1 mAb usages are as follows: Nivolumab, 360mg solution intravenously once daily, Q3W; OR Pembrolizumab/Sintilimab, 200mg solution intravenously once...” NCT06728657 ↗ “OCTOPUS-1, an open-label, randomized phase II study, assessed the efficacy and safety of adding low-dose nivolumab (programmed death 1 inhibitor) to JNJ-73763989 + nucleos(t)ide analog.” PMID 42320551 ↗ Jun 2026 “ICIs:Nivolumab/Pembrolizumab/Durvalumab/Atezolizumab/ Camrelizumab/Dupilumab/Sintilimab/Tislelizumab:administrated for patients with NSCLC requiring post-operative adjuvant therapy.” NCT05834413 ↗ “Current treatments include anti-CD30 (Brentuximab-Vedotin) and PD-1 inhibitors (Nivolumab or Pembrolizumab), often in combination with Autologous Stem Cell Transplantation (ASCT).” PMID 41522540 ↗ Feb 2025 “Nivolumab injection OPDIVO® will start on day 1 of the first cycle IC and continue every 3 weeks for 6 cycles till the end of IMRT, involving the whole-course of IC + IMRT alone.” NCT03984357 ↗ “Immune checkpoint inhibitor (Nivolumab OR Pembrolizumab OR Atezolizumab) PLUS Radiation Therapy (Stereotactic Body Radiation Therapy OR fractionated radiation therapy)” NCT03313804 ↗ “therapy with avelumab, cemiplimab, ipilimumab, nivolumab, pembrolizumab or relatlimab, or currently approved standard of care treatment, either alone or in combination” NCT05358938 ↗ “Combining a WT1 Cancer Vaccine (Galinpepimut-S) With Checkpoint Inhibition (Nivolumab) in Patients With WT1-Expressing Malignant Pleural Mesothelioma: A Phase I Study” NCT04040231 ↗ “Examples include PD-1/PD-L1 inhibitors (e.g., pembrolizumab, nivolumab, camrelizumab, sintilimab) Administered per standard dosing schedule (e.g., every 2-3 weeks)” NCT07277777 ↗ “Nivolumab 240mg intravenously every 2 weeks (days 14, 28, 42, and 56 for a total of four doses), in combination with Cabozantinib 40mg by mouth daily for 8 weeks.” NCT03299946 ↗ “Starting Day 14: Nivolumab application 240 mg i.v. over 30 minutes ever 2 weeks with a maximum to 2 years, or until disease progression or inacceptable toxicity.” NCT04165967 ↗ “PD-1 inhibitor (pembrolizumab or nivolumab) will be administered via a 30-minute intravenous infusion until disease progression or unacceptable toxicity.” NCT05838729 ↗ “Pembrolizumab, 200mg, Q3W or Nivolumab, 3mg/kg, Q2W or Tislelizumab,200mg,Q3W or Camrelizumab,200mg,Q3W or Sintilimab,200mg,Q3W or Toripalimab,240mg,Q3W” NCT06170710 ↗ “After 3 months after autologous blood stem cell transplantation, maintenance therapy with nivolumab 3 mg/kg every 2 weeks for 6 months will be started.” NCT05425654 ↗ “Patients will be treated with 2 cycles of i.v. ipilimumab 1mg/kg and nivolumab 3mg/kg q3w, followed by continued i.v. nivolumab 480mg q4w up to 1 year.” NCT06519266 ↗ “Clinical trials have shown that PD-1 inhibitors (such as pembrolizumab and nivolumab) can shrink tumours and extend the life of patients with melanoma.” NCT02821013 ↗ “Nivolumab 1 mg/kg solution IV combined with ipilimumab 3 mg/kg solution IV every 3 weeks for 4 doses then nivolumab 3 mg/kg solution IV every 2 weeks” NCT02631447 ↗ “If a PD-1 inhibitor is administered in combination, tislelizumab (200 mg), or pembrolizumab (200 mg), or nivolumab (360 mg), iv, day1, q3w.” NCT06841679 ↗ “This study compares systemic immune effects of intradermal versus standard intravenous CTLA-4 administration, both combined with nivolumab.” NCT07615881 ↗ “Patients will receive EU-sourced OPDIVO® (EU-sourced nivolumab) (1 mg/kg) treatment on the first day of each 3-week cycle, up to 4 cycles.” NCT07176650 ↗ “including nivolumab (3mg/kg, ivgtt, q2w), Carelizumab (200mg, ivgtt, q3w), Sintilimab (200mg, ivgtt, q3w), Toripalimab(240mg ivgtt, q3w).” NCT04110093 ↗ “Combination of a PD-1 inhibitor (e.g., Pembrolizumab or Nivolumab) with CAPOX or FOLFOX chemotherapy for a specified number of cycles.” NCT07214142 ↗ “Nivolumab will be administered as an intravenous infusion every 2 weeks at a dose of 3 mg/kg for up to a total period of one year.” NCT02828098 ↗ “Nivolumab: Patients will receive 240 mg nivolumab (dissolved in 250 mL NaCl 0.9%) administered intravenously over 30 minutes.” NCT06047015 ↗ “Patients will have a baseline CD8 PET scan prior to receiving one dose of neoadjuvant nivolumab 1mg/kg + ipilimumab 3mg/kg.” NCT05289193 ↗ “Opdualag, a fixed-dose combination of Nivolumab 480mg and Relatlimab 160mg, intravenous, on day 1, 28 day cycle, 26 cycles” NCT06208657 ↗ “PD-1 inhibitor (Sintilimab, Camrelizumab, Tislelizumab, Toripalimab, Pembrolizumab, Nivolumab), 200mg/dose, iv drip, q3w.” NCT07537985 ↗ “HLX13 (3 mg/kg) and nivolumab (1 mg/kg) treatment on the first day of each cycle, every 3 weeks with a total of 4 cycles” NCT06841185 ↗ “checkpoint inhibitors Nivolumab (antiPD-L1) and Ipilimumab (antiCTLA4) in the post-vaccine phase and during maintenance.” NCT03879512 ↗ “Patients with metastatic malignant melanoma treated in the first line with PD-1 inhibitors (pembrolizumab or nivolumab).” NCT07428252 ↗ “PD-1 inhibitors in this study include, but not limited to, Pembrolizumab, nivolumab, sintilimab, toripalimab, etc.” NCT05509478 ↗ “Optional immune checkpoint inhibitors include Camrelizumab, Sintilimab, Nivolumab, Pembrolizumab, and Toripalimab.” NCT05233358 ↗ “Other alternatives include nivolumab-ipilimumab-chemotherapy or durvalumab-tremelimumab-chemotherapy association.” NCT06840782 ↗ “BMS-936558 (Nivolumab) Versus Investigator's Choice in Advanced (Unresectable or Metastatic) Melanoma Patients” NCT01721746 ↗ “PD-1: Nivolumab(360mg IV d1, Q3W);Sintilimab(200mg IV d1, Q3W);Tislelizumab(200mg IV d1, Q3W) can be selected;” NCT05721651 ↗ “Ipilimumab 1 mg/kg every 6 weeks and Nivolumab 360 mg every 3 weeks or 3 mg/kg every 2 weeks for up to 2 years” NCT04334759 ↗ “investigator's choice of immune checkpoint inhibitor [nivolumab, pembrolizumab, or atezolizumab] or docetaxel” PMID 37657460 ↗ Sep 2023 “The treatment schedule is based on 4 courses of intralesional T-VEC and 3 courses of intraveneous Nivolumab.” NCT04330430 ↗ “PD-1 inhibitor includes pembrolizumab,Nivolumab,Sintilimab,tislelizumab,Triplimab,Camrelizumab, Serplulimab.” NCT06702566 ↗ “combined with immune checkpoint inhibitors Nivolumab in the treatment of patients with advanced solid tumors” NCT05122572 ↗ “Nivolumab, a human immunoglobulin G4 (IgG4) monoclonal antibody that blocks PD-1 (anti PD-1) treatment” NCT04521075 ↗ “Nivolumab or Pembrolizumab or Tislelizumab or Serplulimab or Toripalimab or Sintilimab or Camrelizumab” NCT06084897 ↗ “single-agent anti-PD-1 either nivolumab or pembrolizumab at the discretion of the treating physician” NCT05303493 ↗ “Patients will undergo one single session of HIFU-HT during treatment with ipilimumab and nivolumab.” NCT06524570 ↗ “Nivolumab 360mg 6 weekly (up to 2 years) + XELOX Nivolumab 240mg 4 weekly (up to 2 years) + FOLFOX” NCT06422403 ↗ “Metronomic TMZ 50mg/m2/day orally for 3 months then nivolumab 240mg IV +/- TMZ until progression.” NCT04984733 ↗ “A Phase 1 Study of Nivolumab (BMS-936558) in Subjects With Advanced or Recurrent Malignancies” NCT00730639 ↗ “in combination with Opdivo (Nivolumab) in adult patients with metastatic colorectal cancer” NCT03791398 ↗ “Opdualag (nivolumab 480mg and relatlimab 160mg) will be given every 4 weeks for two years” NCT05077280 ↗ “filtration through the ImmunicomAIAC followed by Nivolumab Administrated IV starting C2.” NCT04142931 ↗ “brentuximab vedotin x 2; nivolumab x 2; vinblastine x2; dacarbazine x 2; rituximab x 2;” NCT05253495 ↗ “Nivolumab (Opdivo®) Monotherapy - 240 mg administered intravenously every 2 weeks (Q2W)” NCT07574047 ↗ “Bristol-myers squibb (BMS) company's nivolumab injection liquid (trade name: odiwal).” NCT04331626 ↗ “Nivolumab and Ipilimumab (sequential) for a total of four doses followed by Nivolumab” NCT06566391 ↗ “NureCombo trial: 4 cycles of 360 mg nivolumab, every 3 weeks, added to nab-paclitaxel” NCT06341478 ↗ “either avelumab, atezolizumab, nivolumab, pembrolizumab, trastuzumab or cetuximab” NCT05069935 ↗ “Nivolumab is a potent human immunoglobulin G4 (IgG4) monoclonal antibody (mAb).” NCT07090148 ↗ “The ICI will be either nivolumab or pembrolizumab and dosing will be per SOC.” NCT06063681 ↗ “Nivolumab (optional, in-line with labelled approval) - 240 mg every 2 weeks” NCT05332002 ↗ “LINNOVATE: Lurbinectedin, Ipilimumab and Nivolumab for Soft Tissue Sarcoma” NCT05876715 ↗ “Study drug: Nivolumab iv infusion 6 mg/kg (max 480 mg) every 4th week.” NCT04644432 ↗ “240 mg flat dose of nivolumab intravenously as a 30-minutes infusion” NCT04525638 ↗ “Nivolumab/Toripalimab 240mg solution intravenously once daily, Q2W.” NCT06121700 ↗ “the immunotherapy (pembrolizumab and nivolumab versus atezolizumab)” NCT05111197 ↗ “Nivolumab: 3mg/kg/day(Children) or 240mg/day(Adults) on Day1,15” NCT05608148 ↗ “anti-programmed cell death protein 1 (PD-1) antibody nivolumab” PMID 42432293 ↗ Jul 2026 “Monotherapy phase - Nivolumab - 40 mg every 14 days x 2 cycles” NCT07234487 ↗ “nivolumab, an antibody against Programmed Cell Death 1 (PD-1)” NCT04627246 ↗ “Celecoxib 400 mg/day in combination with nivolumab fixed dose” NCT03864575 ↗ “Fixed dose combination of relatlimab and nivolumab (Opdualag)” NCT07644312 ↗ “Nivolumab 240mg or 3 mg/kg once every 2 weeks (14 day cycle)” NCT03035890 ↗ “Biological: Nivolumab 240 mg via IV infusion every 14 days” NCT06884683 ↗ “Nivolumab was administered on day 1 for each 14-day cycle.” PMID 36575361 ↗ Dec 2022 “Nivolumab at a dose of 360 mg every 3 weeks for 16 cycles” NCT05468138 ↗ “Checkpoint Inhibitor (Nivolumab 240 mg every 2 weeks)” NCT05063058 ↗ “PD-1 inhibitor: Nivolumab 3mg/kg, or SHR-1210 200mg.” NCT03311789 ↗ “fixed dose of Nivolumab (240 mg, IV infusion) Q2W” NCT07376707 ↗ “Nivolumab 360mg/3 weeks or 240mg /2 weeks, iv, D1” NCT06888037 ↗ “The dose of nivolumab will be fixed at 240 mg.” NCT03527108 ↗ “Nivolumab is a monoclonal anti-PD-1 antibody.” NCT06773910 ↗ “nivolumab (Opdivo) with ipilimumab (Yervoy)” NCT04079166 ↗ “the anti-PD-1 monoclonal antibody Nivolumab” NCT03903458 ↗ “Immunotherapy: nivolumab or pembrolizumab” NCT07000253 ↗ “Nivolumab (Anti-PD-1 Monoclonal Antibody)” NCT05134948 ↗ “Nivolumab 240 mg IV 1 q 2 weeks” NCT04510597 ↗ “Nivolumab 3 mg/kg every 2 weeks” NCT05254184 ↗ “Nivolumab 240 mg every 2 weeks” NCT07130032 ↗ “Either Nivolumab (Opdivo), OR” NCT02423863 ↗ “Drug: Nivolumab (Opdivo®) IV” NCT05053295 ↗ “CBP501, CDDP plus Nivolumab” NCT03113188 ↗ “Nivolumab and pembrolizumab” NCT05108623 ↗ “PD-1 inhibitor (Nivolumab)” NCT05228119 ↗ “Nivolumab + Relatlimab” NCT02935634 ↗ “anti-PD-1 (Nivolumab)” NCT04951583 ↗ “* Nivolumab (Opdivo™)” NCT03246958 ↗ “Optiva (nivolumab)” NCT04157985 ↗ “nivolumab (OPDIVO)” NCT03009058 ↗ “Opdivo (Nivolumab)” NCT03245021 ↗ “Drug: Nivolumab” NCT03872947 ↗ “Drug: Nivolumab” NCT03570619 ↗ “Nivolumab” NCT05257590 ↗ “nivolumab” NCT03544723 ↗ “Nivolumab” NCT05429866 ↗ “nivolumab” NCT05846646 ↗ “Nivolumab” NCT05008861 ↗ “Nivolumab” NCT03997474 ↗ “Nivolumab” NCT06031597 ↗ “Nivolumab” NCT05704985 ↗ “Nivolumab” NCT04954599 ↗ |
| Known as | ABP 206 | “ABP 206” NCT06064097 ↗ |
| Known as | BCD-263 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06640530 ↗ |
| Known as | BMS-936558 | “Nivolumab (BMS-936558) is a fully human, IgG4 (kappa) isotype mAb that binds PD-1 on activated immune cells and disrupts engagement of the receptor with its ligands PD-L1 (B7...” NCT04015778 ↗21“Expanded Access Program With Nivolumab (BMS-936558) in Combination With Ipilimumab (Yervoy®) in Subjects With Unresectable or Metastatic Melanoma” NCT02186249 ↗ “TITAN-TCC (0416-ASG) is a Phase 2, open-label study of nivolumab (BMS-936558) monotherapy with additional nivolumab/ipilimumab "boost" cycles” NCT03219775 ↗ “Non-Comparative, Multi-Cohort, Single Arm, Open-Label, Phase 2 Study of Nivolumab (BMS-936558) in Classical Hodgkin Lymphoma (cHL) Subjects” NCT02181738 ↗ “Nivolumab (BMS-936558) in Chinese Subjects With Previously Treated Advanced or Recurrent Solid Tumors” NCT02593786 ↗ “Nivolumab (also referred to as BMS-936558 or MDX1106) is a human monoclonal antibody” NCT02992964 ↗ “investigational drug called nivolumab (also known as BMS-936558) in glioblastoma” NCT03452579 ↗ “treated with Nivolumab (BMS-936558) at a dose of 3 mg/kg every two weeks.” NCT02156804 ↗ “Nivolumab (BMS-936558) combined with Ipilimumab vs standard of care” NCT03075423 ↗ “nivolumab (BMS-936558, Anti PD-1 Monoclonal Antibody)” NCT02598960 ↗ “Relatlimab (BMS-986016) With Nivolumab (BMS-936558)” NCT04913922 ↗ “The antiviral potential of BMS-936558 (MDX-1106)” PMID 23717490 ↗ May 2013 “nivolumab (also known as Opdivo® , BMS-936558)” NCT02335918 ↗ “With Nivolumab (BMS-936558) Monotherapy” NCT02409368 ↗ “BMS-936558 (Nivolumab)” NCT01721772 ↗ “BMS-936558” NCT03220009 ↗ |
| Known as | BMS-936558 (Nivolumab) | “BMS-936558 (Nivolumab)” NCT02869789 ↗1“BMS-936558 (Nivolumab)” NCT03143153 ↗ |
| Known as | BMS-936558-01 | “Product Description: Nivolumab (BMS-936558-01) Injection drug product is a sterile, non-pyrogenic, single-use, isotonic aqueous solution formulated in 10 mg/ml.” NCT04564157 ↗4“Dosage Form: Nivolumab BMS-936558-01 Solution for Injection Potency: 100 mg (10 mg/mL)” NCT03177239 ↗ “Nivolumab (BMS-936558-01), 480 mg intravenous (every 4 weeks)” NCT04572451 ↗ “Nivolumab (BMS-936558-01) Injection drug product” NCT05684276 ↗ |
| Known as | BMS-986298 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2108738 ↗ |
| Known as | CMAB819 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04659369 ↗ |
| Known as | EO2040 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT05350501 ↗ |
| Known as | Identification code of the investigational drug; BMS-936558, MDX1106, ONO-4538 | “Identification code of the investigational drug; BMS-936558, MDX1106, ONO-4538” NCT03406871 ↗ |
| Known as | MDX1106 | “Nivolumab (also referred to as BMS-936558 or MDX1106) is a human monoclonal antibody” NCT02992964 ↗3“The antiviral potential of BMS-936558 (MDX-1106)” PMID 23717490 ↗ May 2013 “BMS-936558 (MDX-1106)” NCT01024231 ↗ |
| Known as | MDX1106-04 | “BMS-936558 (MDX1106-04)” NCT01024231 ↗ |
| Known as | nivo | “In the MATISSE trial, the primary objective was met to investigate the pathological response rate on neoadjuvant nivolumab (NIVO) and nivolumab plus ipilimumab (NIVO + IPI) at...” PMID 41062829 ↗ Oct 202526“We conducted a multicenter, open-label, randomized phase 2 study to assess the efficacy of nivolumab (Nivo) as maintenance therapy for patients with acute myeloid leukemia...” PMID 39928953 ↗ May 2025 “CA209-7AL is a randomized, multicenter, phase 2 trial evaluating the efficacy and safety of consolidative nivolumab (NIVO) versus observation following neoadjuvant NIVO plus...” PMID 41016926 ↗ Sep 2025 “This phase II cohort from the international, single-arm PIVOT-02 study evaluated the CD122-preferential interleukin-2 pathway agonist bempegaldesleukin (BEMPEG) plus nivolumab...” PMID 34255535 ↗ Jul 2021 “The aim of this open-label, phase III CheckMate 498 study was to evaluate the efficacy of nivolumab (NIVO) + RT compared with TMZ + RT in newly diagnosed GBM with unmethylated...” PMID 35419607 ↗ Jan 2023 “NRG Oncology BN002 (phase I) demonstrated safety and suggested efficacy of ipilimumab (ipi) with nivolumab (nivo) in newly diagnosed glioblastoma, leading to this phase II/III trial.” PMID 40779733 ↗ Aug 2025 “BACKGROUND: As for squamous (Sq)-NSCLC, Checkmate-017 trial showed a significant overall survival (OS) improvement in favor of Nivolumab (Nivo) over Docetaxel in 2nd-line.” PMID 39700681 ↗ Dec 2024 “OBJECTIVE: To investigate the safety and antitumor activity of SEL, nivolumab (NIVO), and ipilimumab (IPI) in Asian patients with treatment-refractory solid organ cancers.” PMID 40502306 ↗ Jun 2025 “PURPOSE: Nivolumab (NIVO) + ipilimumab (IPI) combination and NIVO monotherapy have demonstrated durable clinical benefit in patients with unresectable/metastatic melanoma.” PMID 39504507 ↗ Nov 2024 “This is a multicenter, phase II trial of relatlimab (rela), nivolumab (nivo), and ipilimumab (ipi) in patients with asymptomatic and symptomatic melanoma brain metastases.” NCT06712927 ↗ “We conducted a prospective clinical trial testing nivolumab (NIVO) + tacrolimus (TACRO) + prednisone (PRED) ± ipilimumab (IPI) in KTR with advanced cutaneous cancers.” PMID 38252910 ↗ Jan 2024 “Patients with previously untreated, unresectable, or metastatic melanoma were randomly assigned 1:1 to receive BEMPEG plus nivolumab (NIVO) or NIVO monotherapy.” PMID 37651676 ↗ Aug 2023 “Nivolumab (NIVO), a PD-1 inhibitor, has been shown to prolong survival in patients with advanced melanoma and recurrence-free survival in the adjuvant setting.” PMID 35073733 ↗ Jan 2022 “Standard-of-care treatments for patients with resected stage III/IV melanoma include the immuno-oncology (IO) agents nivolumab (NIVO) and ipilimumab (IPI).” PMID 39378385 ↗ Oct 2024 “This study evaluated andecaliximab (ADX), an inhibitor of MMP9, in combination with nivolumab (NIVO), for the treatment of advanced gastric cancer.” PMID 34893523 ↗ Dec 2021 “We applied mixture cure models (MCMs) to the adjuvant nivolumab (NIVO) and placebo (PBO) arms of the intention-to-treat (ITT) population” PMID 40204616 ↗ Mar 2025 “The addition of low dose ipilimumab (IPI) to a regimen of adjuvant nivolumab (NIVO) in CheckMate-915 did not result in increased RFS.” PMID 36450385 ↗ Nov 2022 “patients were randomized to the nivolumab plus ipilimumab arm (NIVO + IPI n = 45), or to the capecitabine arm (CT n = 50).” PMID 41314029 ↗ Nov 2025 “Nivolumab (NIVO), which is an anti-PD-1 antibody, has shown promising results in 2nd line treatment for advanced NSCLC.” NCT04263051 ↗ “nivolumab (NIVO) with or without ipilimumab (IPI) in virus-associated cancers” PMID 39889250 ↗ Jan 2025 “In this phase 1/2 study, brentuximab vedotin (BV) and nivolumab (Nivo)” PMID 29229594 ↗ Dec 2017 “nivolumab (nivo; 240 mg every second week)” PMID 38242720 ↗ Jan 2024 “nivolumab (nivo, anti-PD-1)” PMID 37620627 ↗ Aug 2023 “nivolumab (nivo; anti-PD-1)” PMID 35662283 ↗ Jun 2022 “nivolumab (NIVO)” NCT03832621 ↗ “nivolumab (NIVO)” PMID 36808285 ↗ Aug 2023 “nivolumab (NIVO)” NCT07546812 ↗ |
| Known as | Nivo800 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07460765 ↗ |
| Known as | Nivolimumab | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03278626 ↗ |
| Known as | Nivolumab (OPDIVO) | “Nivolumab (OPDIVO)” NCT02460068 ↗3“nivolumab (opdivo)” NCT03026140 ↗ “nivolumab (Opdivo)” NCT04250246 ↗ “nivolumab (OPDIVO)” NCT03009058 ↗ |
| Known as | Nivolumab (Opdivo) BMS-936558-01 | “Nivolumab (Opdivo) BMS-936558-01” NCT03003637 ↗ |
| Known as | Nivolumab + Relatlimab FDC | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07492680 ↗ |
| Known as | Nivolumab and Recombinant Human Hyaluronidase | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07383441 ↗ |
| Known as | Nivolumab Biosimilar BCD-263 | “Nivolumab Biosimilar BCD-263” NCT06029270 ↗ |
| Known as | Nivolumab Biosimilar CMAB819 | “Nivolumab Biosimilar CMAB819” NCT06029270 ↗ |
| Known as | Nivolumab bms | ChEMBL registry synonym — accepted as the source's own label CHEMBL2108738 ↗ |
| Known as | Nivolumab component of bms-986213 | ChEMBL registry synonym — accepted as the source's own label CHEMBL2108738 ↗ |
| Known as | Nivolumab component of opdualag | ChEMBL registry synonym — accepted as the source's own label CHEMBL2108738 ↗ |
| Known as | Nivolumab Injection | “A Randomized, Double-blind, Multicenter, Phase 3 Study to Compare the Efficacy and Safety of LY01015 and Opdivo®(Nivolumab Injection)Combined Respectively With Fluorouracil...” NCT06022861 ↗ |
| Known as | nivolumab-IRDye800CW | “evaluate the safety and feasibility of nivolumab-IRDye800CW (nivo800) as a molecular imaging agent in adults with biopsy-confirmed or presumed head and neck squamous cell...” NCT07460765 ↗ |
| Known as | Nivolumab: OPDIVO/ BMS-936558/ MDX1106/ ONO-4538; | “Nivolumab: OPDIVO/ BMS-936558/ MDX1106/ ONO-4538;” NCT04326257 ↗ |
| Known as | odiwal | “Bristol-myers squibb (BMS) company's nivolumab injection liquid (trade name: odiwal).” NCT04331626 ↗ |
| Known as | ONO-4538 | “ONO-4538: 360 mg solution intravenously for 30 min in every 3 weeks until RECIST 1.1 defined PD, unacceptable toxicity, or withdrawal of consent.” NCT03117049 ↗ |
| Known as | Opdivo | “This phase I/Ib trial will assess the dose, safety and side effects of the combination of the cancer drugs afatinib (GILOTRIF®) and nivolumab (OPDIVO®) and to assess the...” NCT03652233 ↗59“This phase 1b/2 study evaluates the safety and efficacy of AL3818 (anlotinib) hydrochloride in combination with Opdivo (nivilumab) for the treatment patients with of...” NCT04165330 ↗ “Nivolumab (OPDIVO®) is a human IgG4 kappa immunoglobulin that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated...” NCT03575598 ↗ “Neoadjuvant chemotherapy (2 cycles of cisplatin OR carboplatin accord healthcare- investigator's choice - PLUS pemetrexed fresenius AND immunotherapy (2 cycles of Opdivo PLUS 1...” NCT07121374 ↗ “The purpose of this study is to evaluate how effective the study drugs, nivolumab (also known as Opdivo®) and talazoparib (also known as Talzenna®) are when given as a...” NCT04187833 ↗ “A Pilot Study of Alectinib (Alecensa) in Combination With Nivolumab (Opdivo) in the Treatment of Recurrent or Refractory Hepatocellular Carcinoma Patients Guided With Serum...” NCT06354387 ↗ “Nivolumab (Opdivo®) is a human monoclonal antibody (HuMAb; immunoglobulin G4 (IgG4)- S228P) that targets the PD-1 cluster of differentiation 279 (CD279) cell surface membrane receptor.” NCT03557359 ↗ “Nivolumab injection OPDIVO® will start on day 1 of the first cycle IC and continue every 3 weeks for 6 cycles till the end of IMRT, involving the whole-course of IC + IMRT alone.” NCT03984357 ↗ “Patients will receive EU-sourced OPDIVO® (EU-sourced nivolumab) (1 mg/kg) treatment on the first day of each 3-week cycle, up to 4 cycles.” NCT07176650 ↗ “Nivolumab (Opdivo®)- an anti-PD1 treatment- combined to tisagenlecleucel in a cohort of relapsed or refractory B-ALL patients” NCT05310591 ↗ “One infusion of nivolumab (Opdivo®) 480mg (flat dose) in NaCl (Natriumklorid Baxter Viaflo, 9 mg/ml) during 60 minutes” NCT03685890 ↗ “in combination with Opdivo (Nivolumab) in adult patients with metastatic colorectal cancer” NCT03791398 ↗ “Nivolumab (Opdivo®) Monotherapy - 240 mg administered intravenously every 2 weeks (Q2W)” NCT07574047 ↗ “Biological: Nivolumab 240 mg via IV infusion every 14 days Other Names: Opdivo®” NCT06884683 ↗ “Brand name of regorafenib is Stivarga; brand name of nivolumab is Opdivo.” NCT04126733 ↗ “Nivolumab 10 MG/1 ML Intravenous Solution [OPDIVO]” NCT05909618 ↗ “Nivolumab (also known as Opdivo or BMS-936558)” NCT03177239 ↗ “nivolumab (also known as Opdivo® , BMS-936558)” NCT02335918 ↗ “COM701 in combination with Opdivo (Nivolumab).” NCT03667716 ↗ “nivolumab (Opdivo) with ipilimumab (Yervoy)” NCT04079166 ↗ “Drug: Nivolumab Injection [Opdivo]” NCT03630640 ↗ “Either Nivolumab (Opdivo), OR” NCT02423863 ↗ “Nivolumab Injection [Opdivo]” NCT05223816 ↗ “Nivolumab Injection [Opdivo]” NCT04396821 ↗ “Drug: Nivolumab (Opdivo®) IV” NCT05053295 ↗ “Nivolumab Injection [Opdivo]” NCT03563729 ↗ “Nivolumab Injection [Opdivo]” NCT03518320 ↗ “Nivolumab Injection [Opdivo]” NCT03507699 ↗ “Nivolumab Injection [Opdivo]” NCT05257590 ↗ “Nivolumab Injection [Opdivo]” NCT05385263 ↗ “Nivolumab Injection [Opdivo]” NCT05655715 ↗ “Nivolumab Injection [Opdivo]” NCT05266612 ↗ “Nivolumab Injection [Opdivo]” NCT05964101 ↗ “Nivolumab Infusion [Opdivo]” NCT03815942 ↗ “Nivolumab 10 MG/ML [Opdivo]” NCT05187429 ↗ “Drug: Nivolumab [Opdivo]” NCT05112549 ↗ “* Nivolumab (Opdivo™)” NCT03341936 ↗ “Nivolumab (OPDIVO®)” NCT03669523 ↗ “Opdivo (Nivolumab)” NCT03245021 ↗ “Nivolumab (Opdivo)” NCT07013565 ↗ “Nivolumab (OPDIVO)” NCT04416568 ↗ “Nivolumab (Opdivo)” NCT03721679 ↗ “Nivolumab (Opdivo)” NCT04704154 ↗ “Opdivo” NCT03645928 ↗ “Opdivo” NCT06029270 ↗ |
| Known as | Opdivo (Nivolumab) | “Opdivo (Nivolumab)” NCT03143153 ↗1“Opdivo (Nivolumab)” NCT02869789 ↗ |
| Known as | Opdivo (trade name for Nivolumab) | “Opdivo (trade name for Nivolumab)” NCT04107103 ↗ |
| Known as | OpdivoTM | “Nivolumab (OpdivoTM) is a potent and highly selective humanized monoclonal antibody (mAB) designed to block the interaction between PD-1 and its ligands, PD-L1 and PD-L2.” NCT04021108 ↗2“Nivolumab (OpdivoTM, BMS), a human IgG-4 mAb that blocks the Programmed cell death protein 1 (PD-1, CD279) has demonstrated anti-tumor activity” NCT03233152 ↗ “Nivolumab (OpdivoTM, 40 mg/4mL solution)” NCT07230613 ↗ |
| Known as | Optiva (nivolumab) | “Optiva (nivolumab)” NCT04157985 ↗ |
| Known as | Optivo | “Nivolumab (Optivo®)” NCT04343144 ↗ |
| Known as | PD-1 blocking antibody | ClinicalTrials.gov intervention name — accepted as the source's own label NCT04268537 ↗ |
| Known as | Pembrozilumab | “Pembrozilumab” NCT05429866 ↗ |
| Known as | Single agent Nivolumab | “Single agent Nivolumab” NCT04042753 ↗ |
| Known as | TGI-5 | ClinicalTrials.gov intervention name — accepted as the source's own label NCT07376707 ↗ |
| Action | Inhibit | “blocks ligand binding” PMID 23717490 ↗ May 2013 |
| Modality | Monoclonal antibody | “fully human anti-PD-1 monoclonal” PMID 23717490 ↗ May 2013 |
| Route | Intravenous | “single intravenous (IV) infusion” NCT00441337 ↗ |
| Target | PDCD1 | “anti-programmed cell death 1 (anti-PD-1) therapy” PMID 33914706 ↗ Jun 2021 |