Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis

Summary

25 patients who are diagnosed with Cytomegalovirus (CMV) anterior segment infection, either uveitis or endotheliitis, will be started on 2% guttae ganciclovir, 1 drop 5 times a day for 6 weeks. Following 6 weeks of continuous application of 2% guttae ganciclovir, patient will be reviewed at the clinic within 3 hours following the last application of topical ganciclovir and clinical features will be documented for activity assessment. An aqueous sample 0.2ml is drawn. 0.1ml will be sent for RT-PCR for CMV viral load and another 0.1ml will be sent for ganciclovir drug level by HPLC method.

Timeline

Start

2016-10

Primary completion

2024-01

Completion

2024-11-30

Publications

• Waduthantri S, Zhou L, Chee SP. Aqueous humour concentration of topically applied 2.0% ganciclovir eye drops in eyes with cytomegalovirus anterior uveitis and endotheliitis. Clin Exp Ophthalmol. 2025 May-Jun;53(4):384-390. doi: 10.1111/ceo.14469. Epub 2024 Nov 25.

Drugs

Indications