Drugs / Ganciclovir
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Ganciclovir

Small molecule

Developed for
HIV infectious disease · cytomegalovirus retinitis · cytomegalovirus infection · lymphoma · lymphoproliferative syndrome · colitis · herpes simplex virus keratitis · leukemia
+34 more · acute lung injury · acute respiratory distress syndrome · acute respiratory failure · adenoviridae infectious disease · allergic rhinitis · anterior uveitis · brain disorder · brain neoplasm · cutaneous melanoma · digestive system disorder · disease related to hematopoietic stem cell transplant · endotheliitis · epidemic keratoconjunctivitis · fallopian tube cancer · fetal cytomegalovirus syndrome · hepatocellular carcinoma · KSHV inflammatory cytokine syndrome · lymphoid neoplasm · malignant mesothelioma · metastatic neoplasm · ophthalmic herpes zoster · ovarian cancer · peritoneum cancer · posterior uveitis · precancerous condition · radiculitis · small intestine cancer · viral conjunctivitis · viral infectious disease · conjunctivitis · disease related to solid organ transplantation · keratoconjunctivitis · uveitis · viral pneumonia
Investigated by
Hoffmann-La Roche · National Institute of Allergy and Infectious Diseases (NIAID) · National Cancer Institute (NCI) · Roche Global Development · Fred Hutchinson Cancer Center · HemaQuest Pharmaceuticals Inc.
+60 more · Johns Hopkins University · Louisiana State University Health Sciences Center in New Orleans · National Center for Research Resources (NCRR) · National Heart, Lung, and Blood Institute (NHLBI) · Northwestern University · Roche Pharma AG · Schering-Plough · Singapore National Eye Centre · AIDS Malignancy Consortium · Aier School of Ophthalmology, Central South University · American National Red Cross · Astra USA · Bausch & Lomb Incorporated · Baylor College of Medicine · Beijing YouAn Hospital · Boston Medical Center · Boston University · Chunxiao Wang · City of Hope Medical Center · Federal University of São Paulo · Genentech, Inc. · Hu Bofei · Huazhong University of Science and Technology · Huzhou Maternity and Child Care Hospital · Icahn School of Medicine at Mount Sinai · Ionis Pharmaceuticals, Inc. · Jiangxi Maternal and Child Health Hospital · Jiaxing Maternity and Child Health Care Hospital · John Stoddard Cancer Center at Iowa Methodist Medical Center · Johns Hopkins Bloomberg School of Public Health · Jonsson Comprehensive Cancer Center · Laboratoires Thea · Lower Saxony Center for Nephrology · Memorial Sloan Kettering Cancer Center · NYU Langone Health · National Eye Institute (NEI) · National Human Genome Research Institute (NHGRI) · National Institute for Health Research, United Kingdom · National Institute of Neurological Disorders and Stroke (NINDS) · New York Presbyterian Hospital · Ningbo Women & Children's Hospital · Peking University People's Hospital · Pierrel Research Europe GmbH · Quzhou Maternal and Child Health Care Hospital · Salvador Gil-Vernet · Second Affiliated Hospital of Wenzhou Medical University · Shanghai BDgene Co., Ltd. · Tianjin Medical University · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · University College, London · University Hospital Birmingham NHS Foundation Trust · University of California, Los Angeles · University of California, San Diego · University of California, San Francisco · University of Massachusetts, Worcester · University of Miami · University of Oslo School of Pharmacy · University of Wisconsin, Madison · Washington University School of Medicine · Zhejiang University School of Medicine, Obstetrics and Gynecology Hospital

Regulatory milestones approvals, filings & regulatory actions · 8 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Label expansions (5) US (FDA) CYTOVENE — 1992-05-15 – 2018-08-06 fda.gov ↗
Withdrawn EU (EMA) Vitrasert Implant — 2002-04-02 europa.eu ↗
Approved EU (EMA) Vitrasert Implant — 1997-03-18 europa.eu ↗
Approved US (FDA) CYTOVENE — 1989-06-23 fda.gov ↗

Trials 73

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT05911503 Jul 2023 → Jun 2027 expected cytomegalovirus retinitis Tianjin Medical University Recruiting No outcome recorded
Phase 114 trials
Phase 1 NCT06474416 Sep 2023 → Oct 2025 overdue herpes simplex virus keratitis Shanghai BDgene Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT00093704 Mar 2005 → Jul 2010 lymphoma, lymphoproliferative syndrome Jonsson Comprehensive Cancer Center Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT00005057 Mar 2000 → ? cutaneous melanoma National Human Genome Research Institute (NHGRI) Completed No outcome recorded
Phase 1 NCT00006216 Aug 1997 → ? malignant mesothelioma Louisiana State University Health Sciences Center in New Orleans Unknown No outcome recorded
Phase 1 NCT00006340 Dec 1994 → Jul 2000 leukemia, lymphoma, precancerous condition, small intestine cancer Boston Medical Center Completed No outcome recorded
Phase 1 NCT00001328 Aug 1992 → Apr 2010 brain neoplasm, metastatic neoplasm National Institute of Neurological Disorders and Stroke (NINDS) Completed No outcome recorded
Phase 1 NCT00000805 ? → Mar 1998 HIV infectious disease, cytomegalovirus infection National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00000970 ? → Jun 1993 HIV infectious disease, cytomegalovirus retinitis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00001062 ? → Jan 1998 HIV infectious disease, cytomegalovirus retinitis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 1 NCT00000856 — HIV infectious disease, brain disorder, radiculitis National Institute of Allergy and Infectious Diseases (NIAID) Withdrawn No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT04225780 Feb → Dec 2020 cytomegalovirus infection Peking University People's Hospital Unknown No outcome recorded
Phase 1/2 NCT00031434 Jul 2002 → Jul 2007 cytomegalovirus infection National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 215 trials · 1 met primary · 1 missed
Phase 2 NCT02382588 Dec 2013 → May 2020 ophthalmic herpes zoster Northwestern University Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT01503918 Jan 2012 → Jan 2014 — University Hospital Birmingham NHS Foundation Trust Completed Met primary
Phase 2 NCT01419561 Sep 2011 → Dec 2028 expected KSHV inflammatory cytokine syndrome, human herpesvirus 8 infection National Cancer Institute (NCI) Recruiting No outcome recorded
Phase 2 NCT01335932 Mar 2011 → Jun 2016 acute lung injury, acute respiratory distress syndrome Fred Hutchinson Cancer Center Completed Missed primary
Phase 2 NCT00992732 May → Nov 2010 lymphoid neoplasm, lymphoproliferative syndrome HemaQuest Pharmaceuticals Inc. Terminated No outcome recorded
Phase 2 NCT01156025 Mar 2009 → Feb 2010 epidemic keratoconjunctivitis Laboratoires Thea Completed No outcome recorded
Phase 2 NCT00917826 Sep 2008 → Sep 2009 lymphoma, lymphoproliferative syndrome HemaQuest Pharmaceuticals Inc. Terminated No outcome recorded
Phase 2 NCT02202564 Oct 2006 → Oct 2011 hepatocellular carcinoma Huazhong University of Science and Technology Completed No outcome recorded
Phase 2 NCT00217503 Jul 2005 → Jun 2007 lymphoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00006264 Jul 2000 → Mar 2003 lymphoma AIDS Malignancy Consortium Completed No outcome recorded
Phase 310 trials · 1 missed
Phase 3 NCT04706507 Jun 2021 → Oct 2024 acute respiratory failure Fred Hutchinson Cancer Center Terminated Missed primary
Phase 3 NCT01185223 Sep 2010 → Dec 2012 disease related to hematopoietic stem cell transplant Pierrel Research Europe GmbH Terminated No outcome recorded
Phase 3 NCT00241345 Jun 2004 → Nov 2007 cytomegalovirus infection Washington University School of Medicine Terminated No outcome recorded Stop: Enrollment
Phase 3 NCT00002377 Jan 1997 → Dec 2002 HIV infectious disease, cytomegalovirus retinitis Hoffmann-La Roche Completed No outcome recorded
Phase 3 NCT00004278 Dec 1991 → ? cytomegalovirus infection National Center for Research Resources (NCRR) Completed No outcome recorded
Phase 3 NCT00000136 Mar 1990 → Oct 1991 HIV infectious disease, cytomegalovirus retinitis Johns Hopkins Bloomberg School of Public Health Completed No outcome recorded
Phase 3 NCT00002070 — HIV infectious disease, cytomegalovirus retinitis Schering-Plough Completed No outcome recorded
Phase 3 NCT00000698 ? → Aug 2007 HIV infectious disease, cytomegalovirus retinitis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00000688 ? → Feb 1995 HIV infectious disease, cytomegalovirus retinitis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 3 NCT00001100 ? → Nov 2005 cytomegalovirus infection National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase 48 trials
Phase 4 NCT07450365 Feb 2026 → Dec 2028 expected fetal cytomegalovirus syndrome Hu Bofei Not yet recruiting No outcome recorded
Phase 4 NCT02943057 Oct 2016 → Jan 2024 cytomegalovirus infection Singapore National Eye Centre Completed No outcome recorded
Phase 4 NCT00264368 Dec 2005 → Jun 2007 acute kidney injury, cytomegalovirus infection, multiple organ dysfunction syndrome University of Oslo School of Pharmacy Terminated No outcome recorded
Phase 4 NCT00431353 Apr 2004 → Aug 2008 cytomegalovirus infection Hoffmann-La Roche Completed No outcome recorded
Phase 4 NCT00730769 Mar 2004 → Jul 2007 cytomegalovirus infection Salvador Gil-Vernet Completed No outcome recorded
Phase 4 NCT00947141 Feb 2003 → Dec 2011 — University College, London Completed No outcome recorded
Phase 4 NCT00373165 Aug 2000 → Oct 2003 cytomegalovirus infection Lower Saxony Center for Nephrology Completed No outcome recorded
Phase 4 NCT00000894 ? → Jun 2000 HIV infectious disease, cytomegalovirus retinitis National Institute of Allergy and Infectious Diseases (NIAID) Completed No outcome recorded
Phase not applicable23 trials
— NCT06436534 May 2024 → Oct 2026 expected allergic rhinitis Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting No outcome recorded
— NCT03217474 Jul 2017 → Dec 2018 herpes simplex virus keratitis Chunxiao Wang Unknown No outcome recorded
— NCT03598452 Jan 2014 → Jan 2018 posterior uveitis, viral infectious disease Aier School of Ophthalmology, Central South University Completed No outcome recorded
— NCT01647529 Jul 2012 → Jul 2013 anterior uveitis, cytomegalovirus infection, endotheliitis Singapore National Eye Centre Completed No outcome recorded
— NCT01349452 Aug → Dec 2009 adenoviridae infectious disease, viral conjunctivitis Federal University of São Paulo Completed No outcome recorded
— NCT00004573 — cytomegalovirus infection National Center for Research Resources (NCRR) Unknown No outcome recorded
— NCT00002095 — HIV infectious disease, cytomegalovirus infection Hoffmann-La Roche Completed No outcome recorded
— NCT00001999 — HIV infectious disease, cytomegalovirus retinitis American National Red Cross Completed No outcome recorded
— NCT00002299 — HIV infectious disease, cytomegalovirus retinitis Hoffmann-La Roche Completed No outcome recorded
— NCT00002330 — HIV infectious disease, cytomegalovirus retinitis Roche Global Development Completed No outcome recorded
Comparator or background therapy38 trials
Phase 0 NCT03338777 Background Feb 2020 melanoma Hospital Italiano de Buenos Aires Terminated No outcome recorded
Phase 1 NCT05578820 Background Jan 2022 → Apr 2024 anus neoplasm, breast neoplasm, cervical cancer, head and neck squamous cell carcinoma +4 Gene Surgery LLC Completed No outcome recorded
Phase 1 NCT02188719 Background Dec 2014 → Jun 2019 — National Institute of Allergy and Infectious Diseases (NIAID) Terminated No outcome recorded
Phase 1 NCT00964756 Background Aug 2009 → Dec 2010 ovarian cancer University of Alabama at Birmingham Completed No outcome recorded
Phase 1 NCT00006480 Background May 2000 → Mar 2005 neuroblastoma Fred Hutchinson Cancer Center Completed No outcome recorded

Evidence & citations 27 cited values

Every value below carries the sentence it was read from. 114 sources stand behind the page.

FieldValueCited text
Known as ganciclovir “Valganciclovir (900mg) will be administered orally twice/day or Ganciclovir (5 mg/kg) will be administered i.v. over 1 hour for 14 days for cycle 1 and for 7 days (up to...” NCT01419561 ↗
109

“replication-deficient adenovirus mutant thymidine kinase (ADV-TK) in combination with ganciclovir administration in patients with recurrent high-grade glioma” PMID 26716896 ↗ Jan 2016

“Intravenous ganciclovir and/or oral Valcyte will be administered for the prophylaxis of cytomegalovirus (CMV) and Epstein-Barr Virus (EBV)” NCT02188719 ↗

“Triple-drugs therapy: "Ganciclovir Eye gel+Valacilovir Tablets+Prednisolone Acetate Eye Drops" for 3 weeks.” NCT06474442 ↗

“Triple-drugs therapy: "Ganciclovir Eye gel+Valacilovir Tablets+Prednisolone Acetate Eye Drops" for 3 weeks.” NCT06474416 ↗

“4.2.3 Ganciclovir Dosing: 6 mg/kg/dose IV q12h” NCT05564598 ↗

“Intravenous ganciclovir 5mg/kg twice daily” NCT01220895 ↗

“Intravenous ganciclovir 5mg/kg twice daily” NCT01077908 ↗

“Ganciclovir 1.5 mg/g ophtalmic gel” NCT01156025 ↗

“0.15% ganciclovir gel(Zirgan)” NCT01533480 ↗

“prodrug (ganciclovir: GCV)” NCT03338777 ↗

Show 99 more sources

Known as BW 759U ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Cimeven “Ganciclovir (Cimeven®) will be administrated intravenous twice a day at 12-hour intervals for 15 days.” NCT05578820 ↗
Known as Cymevene ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Cytovene “The first two drugs approved by the United States Food and Drug Administration (FDA) for the treatment of CMV retinitis were ganciclovir (Cytovene) and foscarnet (Foscavir).” NCT00000136 ↗
2

“A drug called ganciclovir (Cytovene) can kill the virus.” NCT00001328 ↗

“Intravenous Cytovene (Ganciclovir Sodium)” NCT00002034 ↗

Known as Cytovene iv ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as DHPG “A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital...” NCT00001100 ↗
9

“The use of ganciclovir (DHPG) in combination with interferon beta to prevent relapse of cytomegalovirus retinitis in patients with AIDS.” NCT00002299 ↗

“Phase I Studies of the Combination of AZT and DHPG (Ganciclovir) in Patients With AIDS and Cytomegalovirus Infection” NCT00000995 ↗

“Intravenous Ganciclovir (DHPG) for Cytomegalovirus Colitis” NCT00002273 ↗

“effectiveness and safety of ganciclovir (DHPG) therapy” NCT00000673 ↗

“intravenous ganciclovir (also known as DHPG)” NCT00000698 ↗

“long-term ganciclovir (DHPG) therapy” NCT00002034 ↗

“injections of ganciclovir (DHPG)” NCT00000688 ↗

“ganciclovir (DHPG)” NCT00001999 ↗

“ganciclovir (DHPG)” NCT00000970 ↗

Known as Dihydroxypropoxymethyl Guanine “A Phase III Study to Evaluate the Safety and Efficacy of Ganciclovir (Dihydroxypropoxymethyl Guanine [DHPG]) Treatment of Symptomatic Central Nervous System (CNS) Congenital...” NCT00001100 ↗
Known as Ganciclovir (as sodium) ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Ganciclovir (Cymevene) “Ganciclovir (Cymevene®)” NCT00730769 ↗
Known as Ganciclovir Ophthalmic Gel “Ganciclovir Ophthalmic Gel” NCT06474416 ↗
Known as Ganciclovir Sodium “Intravenous Cytovene (Ganciclovir Sodium)” NCT00002034 ↗
2

“Cytovene (Ganciclovir Sodium)” NCT00001328 ↗

“Drug: Ganciclovir Sodium” NCT03586284 ↗

Known as Ganciclovir sodium salt ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as gancyclovir ClinicalTrials.gov intervention name — accepted as the source's own label NCT02382588 ↗
Known as Ganzyk-rtu ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as GCV “Treatment of solid-organ transplant (SOT) patients with ganciclovir (GCV)-valganciclovir (VGCV) according to the manufacturer's recommendations may result in over- or underexposure.” PMID 26824942 ↗ Mar 2016
9

“Ganciclovir (GCV) improved the signs and symptoms of CMV retinitis” NCT00000698 ↗

“ganciclovir (GCV) and zidovudine (AZT) when given in combination.” NCT00000995 ↗

“co-administered with GCV (12.5 mg/ml)” NCT03338777 ↗

“Ganciclovir (GCV)” NCT06853184 ↗

“Ganciclovir (GCV)” NCT00964756 ↗

“Ganciclovir (GCV)” NCT03217474 ↗

“Ganciclovir (GCV)” NCT07513623 ↗

“Ganciclovir (GCV)” NCT06971913 ↗

“Ganciclovir (GCV)” NCT06757907 ↗

Known as NSC-759656 ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as RS-21592 ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as RS-21592 SODIUM ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Valganciclovir hydrochloride impurity a ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Virgan ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Vitrasert ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Vitrasert implant ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Known as Zirgan ChEMBL registry synonym — accepted as the source's own label CHEMBL182 ↗
Action Inhibit “arginine butyrate was not only effective in inducing EBV thymidine kinase transcription, but also acted synergistically with the antiviral agent ganciclovir to inhibit cell...” PMID 9628848 ↗ Jun 1998