NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint

Summary

To investigate pain and inflammatory parameters (cytokines, immune cells) in knee joint tissue of chronic arthritis patients following intraarticular (i.a.) injections of morphine, a standard steroid or placebo. The primary hypothesis is that i.a. morphine results in significantly lower pain scores and supplemental analgesic consumption than placebo during the first week after injection, an efficacy comparable to standard i.a. steroid (triamcinolone) medication.

Timeline

Start

2015-08

Primary completion

2021-12

Completion

2021-12

Drugs

Indications