drugset / Trial / NCT02973685
HAIC Versus TACE for Large Hepatocellular Carcinoma Staged BCLC A/B.
Phase 3
Completed
315 enrolled
Sun Yat-sen University
First People's Hospital of Foshan · collabGuangzhou No.12 People's Hospital · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) compared with transarterial chemoembolization (TACE) in patients with large hepatocellular carcinoma staged BCLC A/B.
Timeline
- Start
- 2016-10-01
- Primary completion
- 2020-11-28
- Completion
- 2020-11-28
Publications
- Han X, Peng C, Ruan SM, Li L, He M, Shi M, Huang B, Luo Y, Liu J, Wen H, Wang W, Zhou J, Lu M, Chen X, Zou R, Liu Z. A Contrast-Enhanced Ultrasound Cine-Based Deep Learning Model for Predicting the Response of Advanced Hepatocellular Carcinoma to Hepatic Arterial Infusion Chemotherapy Combined With Systemic Therapies. Cancer Sci. 2025 Jul;116(7):1930-1940. doi: 10.1111/cas.70089. Epub 2025 Apr 29.
- Li QJ, He MK, Chen HW, Fang WQ, Zhou YM, Xu L, Wei W, Zhang YJ, Guo Y, Guo RP, Chen MS, Shi M. Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, and Leucovorin Versus Transarterial Chemoembolization for Large Hepatocellular Carcinoma: A Randomized Phase III Trial. J Clin Oncol. 2022 Jan 10;40(2):150-160. doi: 10.1200/JCO.21.00608. Epub 2021 Oct 14.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Epirubicin | Small molecule | 50 mg | Other |
| Subject | Leucovorin | Small molecule | 400 mg/m2 | Other |
| Comparator | Lobaplatin | Small molecule | 50 mg | Other |
| Comparator | MMC | Unknown | — | Other |
| Subject | Oxaliplatin | Small molecule | 130 mg/m2 | Other |
| Subject | fluorouracil | Small molecule | 2400 mg/m2 | Other |