Efficacy of Three Experimental Toothpastes to Remove Plaque

Completed 75 enrolled GlaxoSmithKline

RandomizedCrossoverOpen-labelTreatment

Summary

The Dose response of three experimental toothpastes (test product 1, test product 2 and test product 3) to remove plaque after a single brushing, compared to a positive control and negative control dentifrice will be evaluated.

Timeline

Start: 2016-12-19
Primary completion: 2017-02-02
Completion: 2017-02-02

Outcome

Missed primary endpoint

paper with no statistically significant difference between them (p = 0.6674). PMID 30942962 ↗

Publications

Results Jose A, Parkinson CR, Manger C, Bielfeldt S, Krause C. Randomized Clinical Dose-Response Study to Evaluate Plaque Removal by Three Experimental Sodium Bicarbonate Toothpastes Using a Single Brushing Model. J Clin Dent. 2018 Dec;29(4):75-80.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium bicarbonate	Diagnostic / imaging agent	0 %	—
Subject	sodium bicarbonate	Diagnostic / imaging agent	20 %	—
Subject	sodium bicarbonate	Diagnostic / imaging agent	35 %	—
Subject	sodium bicarbonate	Diagnostic / imaging agent	50 %	—
Subject	sodium bicarbonate	Diagnostic / imaging agent	67 %	—

Indications

No indication recorded.