CD36 in Nutrient Delivery and Its Dysfunction

Phase 1/2 Completed 26 enrolled Vanderbilt University Medical Center Washington University School of Medicine · collab

NaSingle-groupOpen-labelBasic science

Summary

This proposal will test the hypothesis that chronic treatment with sildenafil with and without the use of nitric oxide substrate, L-arginine, protects against fatty acid induced impairment of endothelial function, improves insulin-stimulated microvascular recruitment, insulin sensitivity and glucose uptake in CD36 rs3211938 G-allele carriers.

Timeline

Start: 2017-01
Primary completion: 2021-07
Completion: 2021-07-31

Publications

Shibao CA, Peche VS, Pietka TA, Samovski D, Williams IM, Abumrad NN, Gamazon ER, Goldberg IJ, Wasserman DH, Abumrad NA. Microvascular insulin resistance with enhanced muscle glucose disposal in CD36 deficiency. Diabetologia. 2025 Mar;68(3):662-675. doi: 10.1007/s00125-024-06292-4. Epub 2024 Nov 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sildenafil	Unknown	20 mg	—

Indications

No indication recorded.