Effect of Timing Progesterone Luteal Support on Embryo Transfer
Summary
The study aims to know whether starting progesterone luteal support in intra cytoplasmic sperm injection (ICSI) cycles on the day of ovum pickup affects the degree of difficulty of embryo transfer compared with starting luteal support on day of embryo transfer
Timeline
- Start
- 2015-11-01
- Primary completion
- 2016-10-30
- Completion
- 2017-01-01
Outcome
Mixed primary results
paper Primary outcome was the overall ratio of difficult ET and ratios on day 3 and 5 ET. PMID 32909190 ↗
paper overall difficult ET (44.1, 24.7) (p = 0.009); PMID 32909190 ↗
paper day 3 difficult ET (23.2, 24.4) (p = 0.45); PMID 32909190 ↗
paper day 5 difficult ET (62.7, 25.6) (p = 0.001). PMID 32909190 ↗
paper starting P4 luteal support on egg retrieval day is associated with significantly higher ratio of difficult embryo transfer PMID 32909190 ↗
Publications
- Background Mochtar MH, Van Wely M, Van der Veen F. Timing luteal phase support in GnRH agonist down-regulated IVF/embryo transfer cycles. Hum Reprod. 2006 Apr;21(4):905-8. doi: 10.1093/humrep/dei437. Epub 2005 Dec 22.
- Background Senciboy D.N and Sharpe-Timms K.L: Progesterone affects the cervix prior to embryo transfer. , Fertility and Sterility ,2001: 76 , Issue 3 , S220 - S221
- Background Ghanem ME, Ragab AE, Alboghdady LA, Helal AS, Bedairy MH, Bahlol IA, Abdelaziz A. Difficult embryo transfer (ET) components and cycle outcome. Which is more harmful?. Middle East Fertility Society Journal. 2016 Jun 30;21(2):114-119
- Ghanem ME, Bedairy MH, Shaaban A, Albahlol IA. Does the Time of Starting Progesterone Luteal Support Affect Embryo Transfer in Long Agonist Protocol Downregulated ICSI Cycles? A Randomized Controlled Trial. Reprod Sci. 2021 Mar;28(3):897-903. doi: 10.1007/s43032-020-00309-0. Epub 2020 Sep 9.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Progesterone | Other / unclassified | 100 mg | Intramuscular |
Indications
No indication recorded.