drugset / Trial / NCT03076281
Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma
Phase 2
Terminated
7 enrolled
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
RandomizedParallel-groupSingle-blindTreatment
Summary
This randomized phase II trial studies how well metformin hydrochloride and doxycycline work in treating patients with head and neck squamous cell carcinoma that can be removed by surgery. Metformin hydrochloride may reduce the metabolic activity of cancer cells and of surrounding supportive tissue. Doxycycline may minimize toxic side effects of anti-cancer therapy. Giving metformin hydrochloride and doxycycline may work better in treating patients with head and neck squamous cell carcinoma.
Timeline
- Start
- 2017-04-03
- Primary completion
- 2018-12-03
- Completion
- 2018-12-03
Outcome
Outcome not reported
Stopped: “Insufficient staff to conduct the trial”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Doxycycline | Small molecule | — | Oral |
| Subject | Metformin | Small molecule | — | Oral |